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Linezolid
Zyvox (linezolid) is a small molecule pharmaceutical. Linezolid was first approved as Zyvox on 2000-04-18. It is used to treat bacterial infections, bacterial pneumonia, bacterial skin diseases, soft tissue infections, and staphylococcal infections amongst others in the USA. It is known to target amine oxidase [flavin-containing] A and amine oxidase [flavin-containing] B.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Zyvox (generic drugs available since 2015-06-03)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Linezolid
Tradename
Company
Number
Date
Products
LINEZOLID IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERHospiraN-206473 RX2015-06-18
1 products, RLD, RS
ZYVOXMylanN-021130 RX2000-04-18
1 products, RLD, RS
ZYVOXMylanN-021131 RX2000-04-18
2 products, RLD, RS
ZYVOXMylanN-021132 RX2000-04-18
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
linezolidNew Drug Application2023-06-19
zyvoxNew Drug Application2023-05-16
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial infections—D001424A49
bacterial pneumoniaEFO_1001272D018410J15.9
bacterial skin diseases—D017192—
soft tissue infections—D018461—
staphylococcal infections—D013203A49.01
streptococcal infectionsEFO_1001476D013290—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01X: Other antibacterials in atc
— J01XX: Other antibacterials in atc
— J01XX08: Linezolid
HCPCS
Code
Description
J2020
Injection, linezolid, 200 mg
Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dry eye syndromesD015352H04.12—4411322
Keratoconjunctivitis siccaD007638EFO_1000906——11—2
Contact lensesD003261———1—1
InflammationD007249———1—1
Corneal diseasesD003316H18.9———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Allergic conjunctivitisD003233EFO_0007141H10.44—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Graft vs host diseaseD006086D89.811————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlaucomaD005901EFO_0000516H40————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLINEZOLID
INNlinezolid
Description
Linezolid is an organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex. It has a role as an antibacterial drug and a protein synthesis inhibitor. It is an oxazolidinone, a member of morpholines, an organofluorine compound and a member of acetamides.
Classification
Small molecule
Drug classoxazolidinone antibacterials
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)NC[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1
Identifiers
PDB—
CAS-ID165800-03-3
RxCUI190376
ChEMBL IDCHEMBL126
ChEBI ID63607
PubChem CID441401
DrugBankDB00601
UNII IDISQ9I6J12J (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
MAOA
MAOA
MAOB
MAOB
Organism
Homo sapiens
Gene name
MAOA
Gene synonyms
NCBI Gene ID
4128
Protein name
amine oxidase [flavin-containing] A
Protein synonyms
MAO-A, Monoamine oxidase type A
Uniprot ID
Q16426
Mouse ortholog
Maoa (17161)
amine oxidase [flavin-containing] A (Q8K0Z8)
Variants
Clinical Variant
No data
Financial
Zyvox - Pfizer
$
€
£
₣
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 21,787 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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7,983 adverse events reported
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