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Decadron w/ xylocaine, Fortacin(lidocaine)
Akten, Duocaine, Embolex, Fortacin, Iontocaine, Lanabiotic, Lidocaton, Lidoderm, Lidosite Topical System, Octocaine, Oraqix, Pliaglis, Rocephin, Terramycin, Xylocaine, Zingo, Ztlido (lidocaine) is a small molecule pharmaceutical. Lidocaine was first approved as Decadron w/ xylocaine on 1982-01-01. It is used to treat burns, cardiac arrhythmias, esophageal diseases, mouth diseases, and pain amongst others in the USA. It has been approved in Europe to treat physiological sexual dysfunction and premature ejaculation. The pharmaceutical is active against sodium channel protein type 5 subunit alpha. In addition, it is known to target transient receptor potential cation channel subfamily V member 6, sodium channel protein type 2 subunit alpha, sodium channel protein type 4 subunit alpha, sodium channel protein type 9 subunit alpha, and sodium channel protein type 10 subunit alpha.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
stomatognathic diseasesD009057
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
psychological phenomenaD011579
mental disordersD001523
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Akten, Lidoderm, Xylocaine, Zingo, Ztlido (generic drugs available since 1982-01-01, discontinued: Alphacaine, Anestacon, Dentipatch, Laryngotracheal anesthesia, Lidocaton, Lidopen, Lta, Rocephin, Xylocaine, Xylocaine viscous, Xylocaine w/ glucose)
Combinations
Oraqix, Pliaglis (generic drugs available since 1982-01-01, discontinued: Decadron w/ xylocaine, Duocaine, Embolex, Emla, Iontocaine, Lanabiotic, Lidocaton, Lidosite topical system, Octocaine, Rocephin, Synera, Terramycin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bupivacaine hydrochloride
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
DUOCAINEAmphastar PharmaceuticalsN-021496 DISCN2003-05-23
1 products
Hide discontinued
Ceftriaxone sodium
Tradename
Company
Number
Date
Products
ROCEPHINRocheN-050585 DISCN1984-12-21
5 products, RLD
Hide discontinued
Ceftriaxone sodium
+
Lidocaine
Tradename
Company
Number
Date
Products
ROCEPHIN KITRocheN-050585 DISCN1996-05-08
2 products
Hide discontinued
Dexamethasone sodium phosphate
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
DECADRON W/ XYLOCAINEMerck KGaAN-013334 DISCN1982-01-01
1 products
Hide discontinued
Dihydroergotamine mesylate
+
Heparin sodium
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
EMBOLEXNovartisN-018885 DISCN1984-11-30
2 products
Hide discontinued
Epinephrine
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
XYLOCAINE W/ EPINEPHRINEFresenius KabiN-006488 RX1982-01-01
6 products, RLD, RS
Show 6 discontinued
Lidocaine
Tradename
Company
Number
Date
Products
ZTLIDOScilex PharmaceuticalsN-207962 RX2018-02-28
1 products, RLD, RS
LIDODERMTeikoku PharmaN-020612 RX1999-03-19
1 products, RLD, RS
Show 5 discontinued
Lidocaine
+
Prilocaine
Tradename
Company
Number
Date
Products
ORAQIXDentsply PharmaceuticalN-021451 RX2003-12-19
1 products, RLD, RS
Show 2 discontinued
Lidocaine
+
Tetracaine
Tradename
Company
Number
Date
Products
PLIAGLISTaro PharmaceuticalN-021717 RX2006-06-29
1 products, RLD, RS
Show 1 discontinued
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019830 RX1992-04-08
1 products
LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019830 RX1992-04-08
1 products
LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019830 RX1992-04-08
1 products
LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-018461 RX1982-02-22
1 products
LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-018461 RX1982-01-01
1 products
LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINERBaxterN-018461 RX1982-01-01
1 products
XYLOCAINEFresenius KabiN-006488 RX1982-01-01
4 products, RLD, RS
LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREEFresenius KabiN-017584 RX1982-01-01
2 products
ZINGOPowder PharmaceuticalsN-022114 RX2007-08-16
1 products
AKTENThea PharmaN-022221 RX2008-10-07
1 products, RLD, RS
Show 21 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
aktenNew Drug Application2022-11-14
anestaconANDA2014-01-10
dentipatch2006-07-24
glydoANDA2020-06-18
lidodermNew Drug Application2022-12-02
lignospan forteANDA2021-06-15
octocaine 50ANDA2011-12-15
oraqixNew Drug Application2018-11-14
pliaglisNew Drug Application2021-01-12
syneraNew Drug Application2020-12-22
Show 3 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
burnsD002056T30.0
cardiac arrhythmiasEFO_0004269D001145I49.9
esophageal diseasesEFO_0009544D004935K22.9
mouth diseasesEFO_1001047D009059K13
painEFO_0003843D010146R52
paroxysmal tachycardiaEFO_0009493D013614I47
ventricular fibrillationEFO_0004287D014693I49.01
ventricular premature complexesD018879I49.3
ventricular tachycardiaD017180I47.2
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Lidocaine Hydrochloride, Zingo, Powder Pharms
93706222035-09-28U-1870
93583382035-04-27U-1870
85406652029-10-22U-1438
Lidocaine, Ztlido, Scilex Pharms
92831742031-05-10DP
99252642031-05-10DPU-2267
99314032031-05-10DP
107656402031-05-10DP
107657492031-05-10DP
112786232031-05-10DP
Lidocaine / Tetracaine, Pliaglis, Taro Pharms
103501802031-01-14DP
106032932031-01-14DP
107513052031-01-14DP
Lidocaine Hydrochloride, Akten, Thea Pharma
87594012026-07-24DPU-1523
ATC Codes
C: Cardiovascular system drugs
C01: Cardiac therapy drugs
C01B: Antiarrhythmics, class i and iii
C01BB: Antiarrhythmics, class ib
C01BB01: Lidocaine
C05: Vasoprotectives
C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
C05AD01: Lidocaine
D: Dermatologicals
D04: Antipruritics, incl. antihistamines, anesthetics, etc.
D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
D04AB: Anesthetics for topical use
D04AB01: Lidocaine
N: Nervous system drugs
N01: Anesthetics
N01B: Local anesthetics
N01BB: Amide local anesthetics
N01BB02: Lidocaine
N01BB52: Lidocaine, combinations
R: Respiratory system drugs
R02: Throat preparations
R02A: Throat preparations
R02AD: Local anesthetic throat preparations
R02AD02: Lidocaine
S: Sensory organ drugs
S01: Ophthalmologicals
S01H: Local anesthetics, ophthalmologic
S01HA: Local anesthetics
S01HA07: Lidocaine
S02: Otologicals
S02D: Other otologicals in atc
S02DA: Analgesics and anesthetics
S02DA01: Lidocaine
HCPCS
Code
Description
C9285
Lidocaine 70 mg/tetracaine 70 mg, per patch
J2001
Injection, lidocaine hcl for intravenous infusion, 10 mg
Clinical
Clinical Trials
1683 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R521232335786208
Postoperative painD010149G89.18512214237114
Local anesthesiaD00077241010141449
AnesthesiaD000758337111638
Healthy volunteers/patients19314531
AnalgesiaD00069833681128
NeuralgiaD009437EFO_000943025461026
Acute painD059787R5213461224
Chronic painD059350HP_001253223441022
Migraine disordersD008881EFO_0003821G432246619
Show 229 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial pneumoniaD018410EFO_1001272J15.9358
VulvodyniaD056650N94.8113138
CoughD003371HP_0012735R0511248
StrokeD020521EFO_0000712I63.914128
Morbid obesityD009767EFO_00010741146
Temporomandibular joint disordersD013705M26.613115
HemorrhoidsD006484EFO_0009552K641335
Premature ejaculationD061686HP_0012876F52.4234
Female genital diseasesD005831EFO_0009549N85134
MalnutritionD044342EFO_0008572E40-E46123
Show 80 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Interstitial cystitisD018856EFO_1000869N30.1628
CataractD002386EFO_0001059H26.91156
Macular degenerationD008268EFO_0001365H35.301134
HyperalgesiaD006930134
PruritusD011537HP_0000989L29134
Inflammatory bowel diseasesD015212EFO_0003767213
EndometriosisD004715EFO_0001065N80213
Chlamydia infectionsD002690EFO_0007205A74.9112
Parkinson diseaseD010300EFO_0002508G20112
Bipolar disorderD001714EFO_0000289F30.9112
Show 45 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nociceptive painD059226156
SciaticaD012585HP_0011868M54.3213
Induced abortionD000028123
Morton neuromaD000070607G57.6213
Radius fracturesD011885EFO_0003957S52.37123
Skin neoplasmsD012878EFO_0004198C44112
EpistaxisD004844EFO_0003895R04.0112
Bowen's diseaseD001913D00-D09112
Brain neoplasmsD001932EFO_0003833C7111
Glycogen storage disease type iiD006009Orphanet_365E74.0211
Show 10 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AgingD000375GO_0007568R41.8177
Needlestick injuriesD01660255
Hand injuriesD00623044
EstheticsD00495444
PregnancyD011247EFO_0002950Z33.133
Female infertilityD007247EFO_0008560N9733
Plantar fasciitisD036981EFO_1001909M72.233
Heart failureD006333EFO_0003144I5033
TendinopathyD052256EFO_1001434M77.922
StrabismusD013285HP_0000486H50.222
Show 132 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLIDOCAINE
INNlidocaine
Description
Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. It has a role as a local anaesthetic, an anti-arrhythmia drug, an environmental contaminant, a xenobiotic and a drug allergen. It is a monocarboxylic acid amide, a tertiary amino compound and a member of benzenes. It is functionally related to a glycinamide.
Classification
Small molecule
Drug classlocal anesthetics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CC(=O)Nc1c(C)cccc1C
Identifiers
PDB3TTR
CAS-ID137-58-6
RxCUI6387
ChEMBL IDCHEMBL79
ChEBI ID6456
PubChem CID3676
DrugBankDB00281
UNII ID98PI200987 (ChemIDplus, GSRS)
Target
Agency Approved
SCN5A
SCN5A
Organism
Homo sapiens
Gene name
SCN5A
Gene synonyms
NCBI Gene ID
Protein name
sodium channel protein type 5 subunit alpha
Protein synonyms
cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit, hH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, sodium channel, voltage-gated, type V, alpha subunit, Voltage-gated sodium channel subunit alpha Nav1.5
Uniprot ID
Mouse ortholog
Scn5a (20271)
sodium channel protein type 5 subunit alpha (Q9JJV9)
Alternate
TRPV6
TRPV6
SCN2A
SCN2A
SCN4A
SCN4A
SCN9A
SCN9A
SCN10A
SCN10A
Organism
Homo sapiens
Gene name
TRPV6
Gene synonyms
ECAC2
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily V member 6
Protein synonyms
Alu-binding protein with zinc finger domain, Calcium transport protein 1, calcium transporter-like protein, CaT-L, CaT-like, CaT1, ECaC2, epithelial apical membrane calcium transporter/channel CaT1, Epithelial calcium channel 2
Uniprot ID
Mouse ortholog
Trpv6 (64177)
transient receptor potential cation channel subfamily V member 6 (Q91WD2)
Variants
Clinical Variant
No data
Financial
Lidocaine - Amneal Pharmaceuticals
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Lidocaine - Amphastar Pharmaceuticals
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Rocephin - Roche
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 69,734 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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47,697 adverse events reported
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