Decadron w/ xylocaine, Fortacin(lidocaine)

Akten, Duocaine, Embolex, Fortacin, Iontocaine, Lanabiotic, Lidocaton, Lidoderm, Lidosite Topical System, Octocaine, Oraqix, Pliaglis, Rocephin, Terramycin, Xylocaine, Zingo, Ztlido (lidocaine) is a small molecule pharmaceutical. Lidocaine was first approved as Decadron w/ xylocaine on 1982-01-01. It is used to treat burns, cardiac arrhythmias, esophageal diseases, mouth diseases, and pain amongst others in the USA. It has been approved in Europe to treat physiological sexual dysfunction and premature ejaculation. The pharmaceutical is active against sodium channel protein type 5 subunit alpha. In addition, it is known to target transient receptor potential cation channel subfamily V member 6, sodium channel protein type 2 subunit alpha, sodium channel protein type 4 subunit alpha, sodium channel protein type 9 subunit alpha, and sodium channel protein type 10 subunit alpha.

Download report

Favorite

Searched

Commercial

Therapeutic Areas

Therapeutic Area	MeSH
digestive system diseases	D004066
stomatognathic diseases	D009057
urogenital diseases	D000091642
cardiovascular diseases	D002318
signs and symptoms pathological conditions	D013568
wounds and injuries	D014947
psychological phenomena	D011579
mental disorders	D001523
musculoskeletal and neural physiological phenomena	D055687

Trade Name

FDA

EMA

Akten, Lidoderm, Xylocaine, Zingo, Ztlido (generic drugs available since 1982-01-01, discontinued: Alphacaine, Anestacon, Dentipatch, Laryngotracheal anesthesia, Lidocaton, Lidopen, Lta, Rocephin, Xylocaine, Xylocaine viscous, Xylocaine w/ glucose)

Combinations

Oraqix, Pliaglis (generic drugs available since 1982-01-01, discontinued: Decadron w/ xylocaine, Duocaine, Embolex, Emla, Iontocaine, Lanabiotic, Lidocaton, Lidosite topical system, Octocaine, Rocephin, Synera, Terramycin)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Bupivacaine hydrochloride

Lidocaine hydrochloride

Tradename	Company	Number	Date	Products
DUOCAINE	Amphastar Pharmaceuticals	N-021496 DISCN	2003-05-23	1 products

Hide discontinued

Ceftriaxone sodium

Tradename	Company	Number	Date	Products
ROCEPHIN	Roche	N-050585 DISCN	1984-12-21	5 products, RLD

Hide discontinued

Ceftriaxone sodium

Lidocaine

Tradename	Company	Number	Date	Products
ROCEPHIN KIT	Roche	N-050585 DISCN	1996-05-08	2 products

Hide discontinued

Dexamethasone sodium phosphate

Lidocaine hydrochloride

Tradename	Company	Number	Date	Products
DECADRON W/ XYLOCAINE	Merck KGaA	N-013334 DISCN	1982-01-01	1 products

Hide discontinued

Dihydroergotamine mesylate

Heparin sodium

Lidocaine hydrochloride

Tradename	Company	Number	Date	Products
EMBOLEX	Novartis	N-018885 DISCN	1984-11-30	2 products

Hide discontinued

Epinephrine

Lidocaine hydrochloride

Tradename	Company	Number	Date	Products
XYLOCAINE W/ EPINEPHRINE	Fresenius Kabi	N-006488 RX	1982-01-01	6 products, RLD, RS

Show 6 discontinued

Lidocaine

Tradename	Company	Number	Date	Products
ZTLIDO	Scilex Pharmaceuticals	N-207962 RX	2018-02-28	1 products, RLD, RS
LIDODERM	Teikoku Pharma	N-020612 RX	1999-03-19	1 products, RLD, RS

Show 5 discontinued

Lidocaine

Prilocaine

Tradename	Company	Number	Date	Products
ORAQIX	Dentsply Pharmaceutical	N-021451 RX	2003-12-19	1 products, RLD, RS

Show 2 discontinued

Lidocaine

Tetracaine

Tradename	Company	Number	Date	Products
PLIAGLIS	Taro Pharmaceutical	N-021717 RX	2006-06-29	1 products, RLD, RS

Show 1 discontinued

Lidocaine hydrochloride

Tradename	Company	Number	Date	Products
LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER	B. Braun Medical	N-019830 RX	1992-04-08	1 products
LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER	B. Braun Medical	N-019830 RX	1992-04-08	1 products
LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER	B. Braun Medical	N-019830 RX	1992-04-08	1 products
LIDOCAINE HYDROCHLORIDE 0.8% AND DEXTROSE 5% IN PLASTIC CONTAINER	Baxter	N-018461 RX	1982-02-22	1 products
LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER	Baxter	N-018461 RX	1982-01-01	1 products
LIDOCAINE HYDROCHLORIDE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER	Baxter	N-018461 RX	1982-01-01	1 products
XYLOCAINE	Fresenius Kabi	N-006488 RX	1982-01-01	4 products, RLD, RS
LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE	Fresenius Kabi	N-017584 RX	1982-01-01	2 products
ZINGO	Powder Pharmaceuticals	N-022114 RX	2007-08-16	1 products
AKTEN	Thea Pharma	N-022221 RX	2008-10-07	1 products, RLD, RS

Show 21 discontinued

Labels

FDA

EMA

Brand Name	Status	Last Update
akten	New Drug Application	2022-11-14
anestacon	ANDA	2014-01-10
dentipatch		2006-07-24
glydo	ANDA	2020-06-18
lidoderm	New Drug Application	2022-12-02
lignospan forte	ANDA	2021-06-15
octocaine 50	ANDA	2011-12-15
oraqix	New Drug Application	2018-11-14
pliaglis	New Drug Application	2021-01-12
synera	New Drug Application	2020-12-22

Show 3 more

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
burns	—	D002056	T30.0
cardiac arrhythmias	EFO_0004269	D001145	I49.9
esophageal diseases	EFO_0009544	D004935	K22.9
mouth diseases	EFO_1001047	D009059	K13
pain	EFO_0003843	D010146	R52
paroxysmal tachycardia	EFO_0009493	D013614	I47
ventricular fibrillation	EFO_0004287	D014693	I49.01
ventricular premature complexes	—	D018879	I49.3
ventricular tachycardia	—	D017180	I47.2

Agency Specific

FDA

EMA

No data

Patent Expiration

Patent	Expires	Flag	FDA Information
Lidocaine Hydrochloride, Zingo, Powder Pharms
9370622	2035-09-28		U-1870
9358338	2035-04-27		U-1870
8540665	2029-10-22		U-1438
Lidocaine, Ztlido, Scilex Pharms
9283174	2031-05-10	DP
9925264	2031-05-10	DP	U-2267
9931403	2031-05-10	DP
10765640	2031-05-10	DP
10765749	2031-05-10	DP
11278623	2031-05-10	DP
Lidocaine / Tetracaine, Pliaglis, Taro Pharms
10350180	2031-01-14	DP
10603293	2031-01-14	DP
10751305	2031-01-14	DP
Lidocaine Hydrochloride, Akten, Thea Pharma
8759401	2026-07-24	DP	U-1523

ATC Codes

C: Cardiovascular system drugs

— C01: Cardiac therapy drugs

— C01B: Antiarrhythmics, class i and iii

— C01BB: Antiarrhythmics, class ib

— C01BB01: Lidocaine

— C05: Vasoprotectives

— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use

— C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use

— C05AD01: Lidocaine

D: Dermatologicals

— D04: Antipruritics, incl. antihistamines, anesthetics, etc.

— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.

— D04AB: Anesthetics for topical use

— D04AB01: Lidocaine

N: Nervous system drugs

— N01: Anesthetics

— N01B: Local anesthetics

— N01BB: Amide local anesthetics

— N01BB02: Lidocaine

— N01BB52: Lidocaine, combinations

R: Respiratory system drugs

— R02: Throat preparations

— R02A: Throat preparations

— R02AD: Local anesthetic throat preparations

— R02AD02: Lidocaine

S: Sensory organ drugs

— S01: Ophthalmologicals

— S01H: Local anesthetics, ophthalmologic

— S01HA: Local anesthetics

— S01HA07: Lidocaine

— S02: Otologicals

— S02D: Other otologicals in atc

— S02DA: Analgesics and anesthetics

— S02DA01: Lidocaine

HCPCS

Code	Description
C9285	Lidocaine 70 mg/tetracaine 70 mg, per patch
J2001	Injection, lidocaine hcl for intravenous infusion, 10 mg

Clinical

Clinical Trials

1683 clinical trials

View more details

Mock data
Subscribe for the real data

Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Pain	D010146	EFO_0003843	R52	12	32	33	57	86	208
Postoperative pain	D010149		G89.18	5	12	21	42	37	114
Local anesthesia	D000772			4	10	10	14	14	49
Anesthesia	D000758			3	3	7	11	16	38
Healthy volunteers/patients	—			19	3	1	4	5	31
Analgesia	D000698			3	3	6	8	11	28
Neuralgia	D009437	EFO_0009430		2	5	4	6	10	26
Acute pain	D059787		R52	1	3	4	6	12	24
Chronic pain	D059350	HP_0012532		2	3	4	4	10	22
Migraine disorders	D008881	EFO_0003821	G43	2	2	4	6	6	19

Show 229 more

Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Bacterial pneumonia	D018410	EFO_1001272	J15.9	—	3	5	—	—	8
Vulvodynia	D056650		N94.81	1	3	1	—	3	8
Cough	D003371	HP_0012735	R05	1	1	2	—	4	8
Stroke	D020521	EFO_0000712	I63.9	1	4	1	—	2	8
Morbid obesity	D009767	EFO_0001074		—	1	1	—	4	6
Temporomandibular joint disorders	D013705		M26.6	1	3	1	—	1	5
Hemorrhoids	D006484	EFO_0009552	K64	1	3	3	—	—	5
Premature ejaculation	D061686	HP_0012876	F52.4	—	2	3	—	—	4
Female genital diseases	D005831	EFO_0009549	N85	—	—	1	—	3	4
Malnutrition	D044342	EFO_0008572	E40-E46	—	1	2	—	—	3

Show 80 more

Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Interstitial cystitis	D018856	EFO_1000869	N30.1	—	6	—	—	2	8
Cataract	D002386	EFO_0001059	H26.9	1	1	—	—	5	6
Macular degeneration	D008268	EFO_0001365	H35.30	1	1	—	—	3	4
Hyperalgesia	D006930			1	3	—	—	—	4
Pruritus	D011537	HP_0000989	L29	—	1	—	—	3	4
Inflammatory bowel diseases	D015212	EFO_0003767		—	2	—	—	1	3
Endometriosis	D004715	EFO_0001065	N80	—	2	—	—	1	3
Chlamydia infections	D002690	EFO_0007205	A74.9	—	1	—	—	1	2
Parkinson disease	D010300	EFO_0002508	G20	—	1	—	—	1	2
Bipolar disorder	D001714	EFO_0000289	F30.9	—	1	—	—	1	2

Show 45 more

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Nociceptive pain	D059226			1	—	—	—	5	6
Sciatica	D012585	HP_0011868	M54.3	2	—	—	—	1	3
Induced abortion	D000028			1	—	—	—	2	3
Morton neuroma	D000070607		G57.6	2	—	—	—	1	3
Radius fractures	D011885	EFO_0003957	S52.37	1	—	—	—	2	3
Skin neoplasms	D012878	EFO_0004198	C44	1	—	—	—	1	2
Epistaxis	D004844	EFO_0003895	R04.0	1	—	—	—	1	2
Bowen's disease	D001913		D00-D09	1	—	—	—	1	2
Brain neoplasms	D001932	EFO_0003833	C71	1	—	—	—	—	1
Glycogen storage disease type ii	D006009	Orphanet_365	E74.02	1	—	—	—	—	1

Show 10 more

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Aging	D000375	GO_0007568	R41.81	—	—	—	—	7	7
Needlestick injuries	D016602			—	—	—	—	5	5
Hand injuries	D006230			—	—	—	—	4	4
Esthetics	D004954			—	—	—	—	4	4
Pregnancy	D011247	EFO_0002950	Z33.1	—	—	—	—	3	3
Female infertility	D007247	EFO_0008560	N97	—	—	—	—	3	3
Plantar fasciitis	D036981	EFO_1001909	M72.2	—	—	—	—	3	3
Heart failure	D006333	EFO_0003144	I50	—	—	—	—	3	3
Tendinopathy	D052256	EFO_1001434	M77.9	—	—	—	—	2	2
Strabismus	D013285	HP_0000486	H50.2	—	—	—	—	2	2

Show 132 more

Epidemiology

Epidemiological information for investigational and approved indications

View more details

Drug

General

Drug common name	LIDOCAINE
INN	lidocaine
Description	Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. It has a role as a local anaesthetic, an anti-arrhythmia drug, an environmental contaminant, a xenobiotic and a drug allergen. It is a monocarboxylic acid amide, a tertiary amino compound and a member of benzenes. It is functionally related to a glycinamide.
Classification	Small molecule
Drug class	local anesthetics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CCN(CC)CC(=O)Nc1c(C)cccc1C

Identifiers

PDB	3TTR
CAS-ID	137-58-6
RxCUI	6387
ChEMBL ID	CHEMBL79
ChEBI ID	6456
PubChem CID	3676
DrugBank	DB00281
UNII ID	98PI200987 (ChemIDplus, GSRS)

Target

Agency Approved

SCN5A

Organism

Homo sapiens

Gene name

SCN5A

Gene synonyms

NCBI Gene ID

6331

Protein name

sodium channel protein type 5 subunit alpha

Protein synonyms

cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit, hH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, sodium channel, voltage-gated, type V, alpha subunit, Voltage-gated sodium channel subunit alpha Nav1.5

Uniprot ID

Q14524

Mouse ortholog

Scn5a (20271)

sodium channel protein type 5 subunit alpha (Q9JJV9)

Alternate

TRPV6

SCN2A

SCN4A

SCN9A

SCN10A

Organism

Homo sapiens

Gene name

TRPV6

Gene synonyms

ECAC2

NCBI Gene ID

55503

Protein name

transient receptor potential cation channel subfamily V member 6

Protein synonyms

Alu-binding protein with zinc finger domain, Calcium transport protein 1, calcium transporter-like protein, CaT-L, CaT-like, CaT1, ECaC2, epithelial apical membrane calcium transporter/channel CaT1, Epithelial calcium channel 2

Uniprot ID

Q9H296

Mouse ortholog

Trpv6 (64177)

transient receptor potential cation channel subfamily V member 6 (Q91WD2)

Variants

Clinical Variant

No data

Financial

Lidocaine - Amneal Pharmaceuticals

€

₣

Mock data
Subscribe for the real data

Lidocaine - Amphastar Pharmaceuticals

€

₣

Mock data
Subscribe for the real data

Rocephin - Roche

€

₣

Mock data
Subscribe for the real data

Tabular view

Trends

PubMed Central

Top Terms for Disease or Syndrome:

Mock data
Subscribe for the real data

Additional graphs summarizing 69,734 documents

View more details

Safety

Black-box Warning

No Black-box warning

Adverse Events

Top Adverse Reactions

Mock data
Subscribe for the real data

47,697 adverse events reported

View more details

Real-time Data on

Companies, Drugs, and Diseases

PharmaKB

MATERIALS

COMPANY