Levosulpiride
Levosulpiride is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against D(2) dopamine receptor and D(3) dopamine receptor. In addition, it is known to target D(4) dopamine receptor.
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Clinical
Clinical Trials
14 clinical trials
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | 1 | — | — | — | 1 | ||
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dyspepsia | D004415 | EFO_0008533 | K30 | 1 | — | — | — | 1 | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Abdominal pain | D015746 | R10.9 | — | — | — | — | 1 | 1 | |
| Abdominal neoplasms | D000008 | — | — | — | — | 1 | 1 | ||
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | 1 | 1 | ||
| Healthy volunteers/patients | — | — | — | — | — | 1 | 1 | ||
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | 1 | |
| Regional blood flow | D012039 | — | — | — | — | 1 | 1 | ||
| Ocular physiological phenomena | D009799 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LEVOSULPIRIDE |
| INN | levosulpiride |
| Description | (S)-(-)-sulpiride is an optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, D1 and D5 receptors respectively). It has a role as a dopaminergic antagonist, an antidepressant, an antiemetic and an antipsychotic agent. It is an enantiomer of a (R)-(+)-sulpiride. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCN1CCC[C@H]1CNC(=O)c1cc(S(N)(=O)=O)ccc1OC |
Identifiers
| PDB | — |
| CAS-ID | 23672-07-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL267044 |
| ChEBI ID | 64119 |
| PubChem CID | 688272 |
| DrugBank | DB00391 |
| UNII ID | JTG7R315LK (ChemIDplus, GSRS) |
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Safety
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0 adverse events reported
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