Levomepromazine
Levoprome (levomepromazine) is a small molecule pharmaceutical. Levomepromazine was first approved as Levoprome on 1982-01-01.
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Abbreviated New Drug Application (ANDA)
Levomepromazine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LEVOPROME | Immunex | N-015865 DISCN | 1982-01-01 | 1 products |
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93 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 2 | 1 | 3 | 1 | 8 |
| Coronary disease | D003327 | — | — | 1 | 2 | 1 | 4 | ||
| Coronary artery disease | D003324 | I25.1 | 1 | — | — | 3 | — | 4 | |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | 1 | 1 | 2 |
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | — | — | 1 | — | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | — | — | — | 1 | — | 1 |
| Coronary stenosis | D023921 | EFO_1000882 | — | — | — | 1 | — | 1 | |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | — | 1 | — | 1 |
| Premature obstetric labor | D007752 | O60 | — | — | — | 1 | — | 1 | |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | 1 | 1 | 1 | — | — | 3 | ||
| Cerebral small vessel diseases | D059345 | — | 2 | 1 | — | — | 2 | ||
| Cardio-renal syndrome | D059347 | — | — | 1 | — | 1 | 2 | ||
| Contraception | D003267 | — | — | 1 | — | — | 1 | ||
| Rupture | D012421 | — | — | 1 | — | — | 1 | ||
| Lacunar stroke | D059409 | I63.81 | — | 1 | 1 | — | — | 1 | |
| Diabetic foot | D017719 | EFO_1001459 | — | — | 1 | — | — | 1 | |
| Oligohydramnios | D016104 | EFO_0007401 | O41.0 | — | 1 | 1 | — | — | 1 |
| Stable angina | D060050 | I20.8 | — | — | 1 | — | — | 1 | |
| Left ventricular dysfunction | D018487 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | 2 | — | — | — | 4 |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 2 | 3 | — | — | — | 4 | |
| Follicular lymphoma | D008224 | C82 | 1 | 2 | — | — | — | 3 | |
| Prostatic neoplasms | D011471 | C61 | 1 | 2 | — | — | — | 2 | |
| Mantle-cell lymphoma | D020522 | C83.1 | 1 | 1 | — | — | — | 2 | |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | 1 | 1 | — | — | — | 2 | |
| Small cell lung carcinoma | D055752 | 1 | 2 | — | — | — | 2 | ||
| Cervical ripening | D020070 | — | 1 | — | — | 1 | 2 | ||
| Induced labor | D007751 | 1 | 2 | — | — | — | 2 | ||
| Proteinuria | D011507 | HP_0000093 | R80 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 5 | — | — | — | 2 | 7 | ||
| Neoplasms | D009369 | C80 | 2 | — | — | — | — | 2 | |
| Therapeutic equivalency | D013810 | 1 | — | — | — | — | 1 | ||
| Multiple myeloma | D009101 | C90.0 | 1 | — | — | — | — | 1 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 1 | — | — | — | — | 1 | |
| Extranodal nk-t-cell lymphoma | D054391 | C86.0 | 1 | — | — | — | — | 1 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 1 | — | — | — | — | 1 | |
| B-cell lymphoma marginal zone | D018442 | C88.4 | 1 | — | — | — | — | 1 | |
| Waldenstrom macroglobulinemia | D008258 | C88.0 | 1 | — | — | — | — | 1 | |
| T-cell lymphoma peripheral | D016411 | C84.9 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | — | — | — | 2 | 2 |
| Headache | D006261 | HP_0002315 | R51 | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 1 | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | — | 1 | 1 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LEVOMEPROMAZINE |
| INN | levomepromazine |
| Description | Methotrimeprazine is a member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist, a serotonergic antagonist, a cholinergic antagonist, a non-narcotic analgesic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an anticoronaviral agent. It is a member of phenothiazines and a tertiary amine. It derives from a hydride of a 10H-phenothiazine. |
| Classification | Small molecule |
| Drug class | Typical antipsychotic |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2 |
Identifiers
| PDB | — |
| CAS-ID | 60-99-1 |
| RxCUI | 6852 |
| ChEMBL ID | CHEMBL1764 |
| ChEBI ID | 6838 |
| PubChem CID | 72287 |
| DrugBank | DB01403 |
| UNII ID | 9G0LAW7ATQ (ChemIDplus, GSRS) |
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Trends
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Safety
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11,075 adverse events reported
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