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Levomenthol
Levomenthol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against transient receptor potential cation channel subfamily M member 8. In addition, it is known to target transient receptor potential cation channel subfamily A member 1 and transient receptor potential cation channel subfamily V member 3.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
sinsinpap coolOTC monograph not final2023-02-27
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gastrointestinal endoscopyD016099——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Inflammatory bowel diseasesD015212EFO_0003767—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PruritusD011537HP_0000989L29————44
PainD010146EFO_0003843R52————11
NeuralgiaD009437EFO_0009430————11
InflammationD007249————11
HyperalgesiaD006930————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLEVOMENTHOL
INNlevomenthol
Description
(-)-menthol is a p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. It has a role as an antipruritic drug, an antitussive and an antispasmodic drug. It is an enantiomer of a (+)-menthol.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Identifiers
PDB—
CAS-ID2216-51-5
RxCUI236388
ChEMBL IDCHEMBL470670
ChEBI ID15409
PubChem CID16666
DrugBankDB00825
UNII IDBZ1R15MTK7 (ChemIDplus, GSRS)
Target
Agency Approved
TRPM8
TRPM8
Organism
Homo sapiens
Gene name
TRPM8
Gene synonyms
LTRPC6, TRPP8
NCBI Gene ID
79054
Protein name
transient receptor potential cation channel subfamily M member 8
Protein synonyms
Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, transient receptor potential subfamily M member 8, Trp-p8, TRPM8 cationic channel
Uniprot ID
Q9BVK1
Mouse ortholog
Trpm8 (171382)
transient receptor potential cation channel subfamily M member 8 (Q8R4D5)
Alternate
TRPA1
TRPA1
TRPV3
TRPV3
Organism
Homo sapiens
Gene name
TRPA1
Gene synonyms
ANKTM1
NCBI Gene ID
8989
Protein name
transient receptor potential cation channel subfamily A member 1
Protein synonyms
ankyrin-like with transmembrane domains 1, Ankyrin-like with transmembrane domains protein 1, p120, Transformation-sensitive protein p120, Wasabi receptor
Uniprot ID
O75762
Mouse ortholog
Trpa1 (277328)
transient receptor potential cation channel subfamily A member 1 (Q8BLA8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 85 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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23 adverse events reported
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