Levocabastine
Livostin (levocabastine) is a small molecule pharmaceutical. Levocabastine was first approved as Livostin on 1993-11-10. It is used to treat allergic conjunctivitis in the USA. It is known to target neurotensin receptor type 2.
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EMA
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levocabastine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LIVOSTIN | Novartis | N-020219 DISCN | 1993-11-10 | 1 products |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| allergic conjunctivitis | EFO_0007141 | D003233 | H10.44 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AC: Antiallergic nasal preparations for topical use, excl. corticosteroids
— R01AC02: Levocabastine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01G: Decongestants and antiallergics
— S01GX: Other antiallergics in atc
— S01GX02: Levocabastine
HCPCS
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Clinical
Clinical Trials
1635 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | G89.18 | 25 | 76 | 53 | 137 | 137 | 405 | |
| Pain | D010146 | EFO_0003843 | R52 | 5 | 13 | 16 | 51 | 39 | 121 |
| Analgesia | D000698 | 4 | 4 | 7 | 14 | 24 | 52 | ||
| Replacement arthroplasty knee | D019645 | 1 | 3 | 1 | 25 | 14 | 44 | ||
| Anesthesia | D000758 | 2 | 6 | 4 | 14 | 19 | 43 | ||
| Spinal anesthesia | D000775 | — | 1 | 4 | 17 | 19 | 41 | ||
| Acute pain | D059787 | R52 | 3 | 8 | 6 | 21 | 7 | 40 | |
| Local anesthesia | D000772 | 3 | 5 | 3 | 7 | 19 | 36 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 9 | 6 | 6 | 9 | 30 |
| Labor pain | D048949 | 2 | 1 | 4 | 10 | 12 | 28 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Video-assisted thoracic surgery | D020775 | — | 1 | 1 | — | 3 | 5 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | 1 | — | 2 | 4 |
| Ventral hernia | D006555 | EFO_1001866 | K43 | 1 | — | 1 | — | 1 | 3 |
| Spinal fusion | D013123 | 1 | — | 1 | — | 1 | 3 | ||
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | 1 | — | 1 | — | 1 | 3 |
| Thoracic diseases | D013896 | — | 1 | 2 | — | 1 | 3 | ||
| Abdominal pain | D015746 | R10.9 | — | 2 | 1 | — | 1 | 3 | |
| Intraoperative complications | D007431 | — | — | 1 | — | 2 | 3 | ||
| Coronary artery disease | D003324 | I25.1 | 1 | — | 2 | — | — | 3 | |
| Female genital neoplasms | D005833 | — | 1 | 2 | — | — | 3 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Herniorrhaphy | D059685 | 1 | 3 | — | — | — | 4 | ||
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | 1 | — | — | 2 | 3 |
| Hernia | D006547 | HP_0100790 | K40-K46 | — | 2 | — | — | 1 | 3 |
| Postherpetic neuralgia | D051474 | 1 | 1 | — | — | 1 | 3 | ||
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | 1 | — | — | 1 | 2 | |
| Phimosis | D010688 | EFO_1001104 | N47.1 | 1 | 1 | — | — | — | 2 |
| Paraphimosis | D010263 | EFO_1001086 | N47.2 | 1 | 1 | — | — | — | 2 |
| Balanitis | D001446 | EFO_1000833 | N48.1 | 1 | 1 | — | — | — | 2 |
| Ankle injuries | D016512 | S93.4 | — | 1 | — | — | 1 | 2 | |
| Thyroid nodule | D016606 | EFO_1001436 | — | 1 | — | — | 1 | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 3 | — | — | — | — | 3 | ||
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | — | — | — | 2 | 3 |
| Sternotomy | D056346 | 2 | — | — | — | — | 2 | ||
| Adenomyosis | D062788 | EFO_1001757 | N80.0 | 1 | — | — | — | 1 | 2 |
| Primary dysautonomias | D054969 | 2 | — | — | — | — | 2 | ||
| Emergence delirium | D000071257 | 1 | — | — | — | 1 | 2 | ||
| Post-dural puncture headache | D051299 | 1 | — | — | — | 1 | 2 | ||
| Sphenopalatine ganglion block | D059387 | 1 | — | — | — | 1 | 2 | ||
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | — | — | — | 2 |
| Parathyroid neoplasms | D010282 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Congenital hip dislocation | D006618 | HP_0001385 | Q65.2 | — | — | — | — | 3 | 3 |
| Postoperative complications | D011183 | — | — | — | — | 3 | 3 | ||
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 3 | 3 |
| Esthetics | D004954 | — | — | — | — | 2 | 2 | ||
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | — | 2 | 2 | |
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | — | — | — | — | 2 | 2 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | — | — | 2 | 2 |
| Confusion | D003221 | F44.89 | — | — | — | — | 2 | 2 | |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | — | 2 | 2 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LEVOCABASTINE |
| INN | levocabastine |
| Description | Levocabastine is a member of piperidines. |
| Classification | Small molecule |
| Drug class | antihistaminics (histamine-H1 receptor antagonists) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H]1CN([C@H]2CC[C@](C#N)(c3ccc(F)cc3)CC2)CC[C@]1(C(=O)O)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 79516-68-0 |
| RxCUI | 28627 |
| ChEMBL ID | CHEMBL1615438 |
| ChEBI ID | — |
| PubChem CID | 54385 |
| DrugBank | DB01106 |
| UNII ID | H68BP06S81 (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Additional graphs summarizing 372 documents
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Safety
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Adverse Events
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398 adverse events reported
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