Lenograstim
Lenograstim is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target granulocyte colony-stimulating factor receptor and macrophage colony-stimulating factor 1 receptor.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Agency Specific
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Clinical
Clinical Trials
998 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | C85.9 | 36 | 112 | 24 | 1 | 11 | 168 | |
| Leukemia | D007938 | C95 | 39 | 81 | 15 | 3 | 8 | 127 | |
| Myelodysplastic syndromes | D009190 | D46 | 32 | 53 | 14 | 1 | 8 | 88 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 25 | 47 | 14 | 4 | 6 | 83 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 12 | 29 | 7 | 1 | 5 | 46 | |
| Neoplasms | D009369 | C80 | 28 | 14 | 6 | 1 | — | 45 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 9 | 26 | 5 | 1 | 7 | 44 | |
| Plasma cell neoplasms | D054219 | 11 | 25 | 5 | 1 | 4 | 43 | ||
| Neutropenia | D009503 | D70 | 6 | 11 | 7 | 1 | 1 | 26 | |
| Graft vs host disease | D006086 | D89.81 | 4 | 5 | 3 | 1 | 5 | 16 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | C92.0 | 33 | 40 | 7 | — | 2 | 69 | |
| Multiple myeloma | D009101 | C90.0 | 20 | 45 | 7 | — | 6 | 69 | |
| Sarcoma | D012509 | 13 | 32 | 9 | — | 1 | 51 | ||
| Neuroblastoma | D009447 | EFO_0000621 | 20 | 20 | 9 | — | 2 | 48 | |
| Central nervous system neoplasms | D016543 | 16 | 27 | 4 | — | 1 | 44 | ||
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 19 | 26 | 3 | — | 2 | 40 |
| Hodgkin disease | D006689 | C81 | 4 | 17 | 7 | — | 2 | 28 | |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 6 | 13 | 1 | — | 3 | 20 | |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | 7 | 12 | 2 | — | 3 | 20 | |
| Myeloproliferative disorders | D009196 | D47.1 | 8 | 8 | 1 | — | 5 | 20 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mantle-cell lymphoma | D020522 | C83.1 | 6 | 12 | — | — | 3 | 18 | |
| Myelodysplastic-myeloproliferative diseases | D054437 | 5 | 8 | — | — | 2 | 14 | ||
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 5 | — | — | 3 | 11 |
| Biphenotypic leukemia acute | D015456 | C95.0 | 6 | 7 | — | — | — | 9 | |
| Fanconi anemia | D005199 | Orphanet_84 | D61.09 | 5 | 6 | — | — | 1 | 9 |
| Fallopian tube neoplasms | D005185 | 5 | 3 | — | — | 1 | 8 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 5 | — | — | 1 | 8 |
| Waldenstrom macroglobulinemia | D008258 | C88.0 | 2 | 4 | — | — | 2 | 7 | |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 3 | 4 | — | — | — | 7 |
| B-cell lymphoma marginal zone | D018442 | C88.4 | 2 | 2 | — | — | 3 | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Astrocytoma | D001254 | EFO_0000271 | 3 | — | — | — | — | 3 | |
| Infertility | D007246 | EFO_0000545 | 1 | — | — | — | 2 | 3 | |
| Squamous cell carcinoma | D002294 | 2 | — | — | — | — | 2 | ||
| Glioma | D005910 | EFO_0000520 | 2 | — | — | — | — | 2 | |
| Oligodendroglioma | D009837 | EFO_0000631 | 2 | — | — | — | — | 2 | |
| Primitive neuroectodermal tumors | D018242 | 2 | — | — | — | — | 2 | ||
| Coronary artery disease | D003324 | I25.1 | 1 | — | — | — | 1 | 2 | |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 2 | — | — | — | — | 2 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 1 | — | — | — | — | 1 |
| Basal cell carcinoma | D002280 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hairy cell leukemia | D007943 | C91.4 | — | — | — | — | 3 | 3 | |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | — | 2 | 2 |
| Diamond-blackfan anemia | D029503 | D61.01 | — | — | — | — | 1 | 1 | |
| Hemophagocytic lymphohistiocytosis | D051359 | D76.1 | — | — | — | — | 1 | 1 | |
| Chediak-higashi syndrome | D002609 | Orphanet_167 | D72.0 | — | — | — | — | 1 | 1 |
| Iga vasculitis | D011695 | EFO_1000965 | D69.0 | — | — | — | — | 1 | 1 |
| Juvenile arthritis | D001171 | EFO_0002609 | M08 | — | — | — | — | 1 | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Giant cell arteritis | D013700 | EFO_1001209 | M31.6 | — | — | — | — | 1 | 1 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | LENOGRASTIM |
| INN | lenograstim |
| Description | Lenograstim is a recombinant granulocyte colony-stimulating factor which functions as an immunostimulator. It is developed by Chugai Pharmaceuticals under the brand name Granocyte.
|
| Classification | Protein |
| Drug class | colony-stimulating factors: granulocyte colony-stimulating factors (G-CSF) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 135968-09-1 |
| RxCUI | 70167 |
| ChEMBL ID | CHEMBL2109128 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB13144 |
| UNII ID | 6WS4C399GB (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CSF3R
CSF3R
CSF1R
CSF1R
Organism
Homo sapiens
Gene name
CSF3R
Gene synonyms
GCSFR
NCBI Gene ID
Protein name
granulocyte colony-stimulating factor receptor
Protein synonyms
CD114, CD114 antigen, colony stimulating factor 3 receptor (granulocyte), G-CSF receptor, G-CSF-R
Uniprot ID
Mouse ortholog
Csf3r (12986)
granulocyte colony-stimulating factor receptor (P40223)
Variants
Clinical Variant
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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738 adverse events reported
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