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Ketoprofen
Actron, Nexcede, Orudis, Oruvail (ketoprofen) is a small molecule pharmaceutical. Ketoprofen was first approved as Orudis on 1986-01-09. It is used to treat dysmenorrhea, osteoarthritis, and rheumatoid arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target sodium-coupled monocarboxylate transporter 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ketoprofen
Tradename
Company
Number
Date
Products
ACTRONBayerN-020499 DISCN1995-10-06
1 products
NEXCEDENovartisN-022470 DISCN2009-11-25
1 products
ORUDISWyethN-018754 DISCN1986-01-09
3 products, RLD
ORUDIS KTWyethN-020429 DISCN1995-10-06
1 products, RLD
ORUVAILWYETH PHARMS INCN-019816 DISCN1993-09-24
3 products, RLD
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dysmenorrheaHP_0100607D004412N94.6
osteoarthritisEFO_0002506D010003M15-M19
rheumatoid arthritisEFO_0000685D001172M06.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
M01: Antiinflammatory and antirheumatic products
M01A: Antiinflammatory and antirheumatic products, non-steroids
M01AE: Propionic acid derivatives, antiinflammatory and antirheumatic products
M01AE03: Ketoprofen
M01AE53: Ketoprofen, combinations
M02: Topical products for joint and muscular pain
M02A: Topical products for joint and muscular pain
M02AA: Antiinflammatory preparations, non-steroids for topical use
M02AA10: Ketoprofen
HCPCS
No data
Clinical
Clinical Trials
85 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R521629
Postoperative painD010149G89.1811316
Cesarean sectionD00258544
Ankle injuriesD016512S93.4224
Low back painD017116HP_0003419M54.5123
LymphedemaD008209Q82.0123
NeuralgiaD009437EFO_000943022
Pain managementD05940811
Recovery of functionD02012711
Renal colicD056844EFO_1001412N2311
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Knee osteoarthritisD020370EFO_0004616M17448
OsteoarthritisD010003EFO_0002506M15-M1955
Migraine disordersD008881EFO_0003821G43415
Musculoskeletal painD059352134
Sprains and strainsD01318044
TendinopathyD052256EFO_1001434M77.9134
BursitisD002062EFO_1000941M71.922
Chronic periodontitisD055113EFO_0006343K05.3111
Postoperative nausea and vomitingD020250EFO_000488811
CholecystectomyD00276311
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Head and neck neoplasmsD00625811
Uterine cervical neoplasmsD00258311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients224
Major depressive disorderD003865EFO_0003761F2211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8022
Post-dural puncture headacheD05129911
Induced abortionD00002811
Ventricular dysfunctionD01875411
Atrial heart septal defectsD006344EFO_1000825Q21.111
Pericardial effusionD010490EFO_0007298I31.3911
HivD006678O98.711
ObesityD009765EFO_0001073E66.911
Female infertilityD007247EFO_0008560N9711
Infantile diarrheaD003968EFO_100130611
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameKETOPROFEN
INNketoprofen
Description
Ketoprofen is an oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2. It has a role as a non-steroidal anti-inflammatory drug, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an environmental contaminant, a xenobiotic and a drug allergen. It is a member of benzophenones and an oxo monocarboxylic acid. It is functionally related to a propionic acid.
Classification
Small molecule
Drug classanti-inflammatory/analgesic agents (ibuprofen type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1
Identifiers
PDB
CAS-ID22071-15-4
RxCUI
ChEMBL IDCHEMBL571
ChEBI ID6128
PubChem CID3825
DrugBankDB01009
UNII ID90Y4QC304K (ChemIDplus, GSRS)
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
SLC5A8
SLC5A8
Organism
Homo sapiens
Gene name
SLC5A8
Gene synonyms
AIT, SMCT, SMCT1
NCBI Gene ID
Protein name
sodium-coupled monocarboxylate transporter 1
Protein synonyms
Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, solute carrier family 5 (iodide transporter), member 8, solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8, Solute carrier family 5 member 8
Uniprot ID
Mouse ortholog
Slc5a8 (216225)
sodium-coupled monocarboxylate transporter 1 (Q8VD01)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 10,588 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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7,939 adverse events reported
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