Ivermectin
Sklice, Soolantra, Stromectol (ivermectin) is an unknown pharmaceutical. Ivermectin was first approved as Stromectol on 1996-11-22. It is used to treat ascariasis, elephantiasis, enterobiasis, lice infestations, and mansonelliasis amongst others in the USA. It is known to target P2X purinoceptor 4, neuronal acetylcholine receptor subunit alpha-7, and P2X purinoceptor 7.
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COVID-19
Case Study: COVID-19
Searched
Commercial
Trade Name
FDA
EMA
Sklice, Soolantra, Stromectol (generic drugs available since 2014-10-24)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ivermectin | ANDA | 2023-06-07 |
| sklice | New Drug Application | 2021-05-13 |
| soolantra | New Drug Application | 2019-11-26 |
| stromectol | New Drug Application | 2020-11-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| ascariasis | EFO_0007154 | D001196 | B77 |
| elephantiasis | EFO_0004711 | D004604 | — |
| enterobiasis | — | D017229 | B80 |
| lice infestations | — | D010373 | B85.2 |
| mansonelliasis | EFO_0007357 | D008368 | B74.4 |
| onchocerciasis | EFO_0007402 | D009855 | B73 |
| scabies | — | D012532 | B86 |
| strongyloidiasis | EFO_0007501 | D013322 | B78 |
| trichuriasis | EFO_0007524 | D014257 | B79 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Ivermectin, Soolantra, Galderma Labs Lp | |||
| 9089587 | 2034-03-13 | U-1631 | |
| 9233117 | 2034-03-13 | U-1631 | |
| 9233118 | 2034-03-13 | U-1631 | |
| 9782425 | 2034-03-13 | U-1631 | |
| 10206939 | 2034-03-13 | U-1631 | |
| 7550440 | 2024-04-22 | DP | U-1631 |
| 8080530 | 2024-04-22 | DP | U-1631 |
| 8093219 | 2024-04-22 | DP | U-1631 |
| 8415311 | 2024-04-22 | DP | U-1631 |
| 8470788 | 2024-04-22 | DP | U-1631 |
| 8815816 | 2024-04-22 | DP | U-1631 |
| 11033565 | 2024-04-22 | DP | |
ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX22: Ivermectin
P: Antiparasitic products, insecticides and repellents
— P02: Anthelmintics
— P02C: Antinematodal agents
— P02CF: Avermectines
— P02CF01: Ivermectin
HCPCS
No data
Clinical
Clinical Trials
192 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | 8 | 32 | 28 | 7 | 14 | 73 | |
| Filarial elephantiasis | D004605 | EFO_0007272 | B74.0 | — | 4 | 4 | 4 | 5 | 16 |
| Scabies | D012532 | B86 | 1 | 2 | 5 | 2 | 3 | 13 | |
| Rosacea | D012393 | L71 | 2 | 2 | 6 | 2 | — | 11 | |
| Onchocerciasis | D009855 | EFO_0007402 | B73 | — | 3 | 4 | 1 | 3 | 11 |
| Malaria | D008288 | EFO_0001068 | B54 | 2 | 3 | 5 | 1 | — | 9 |
| Healthy volunteers/patients | — | 6 | 1 | — | 1 | — | 7 | ||
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 2 | 3 | 1 | 1 | 5 |
| Trachoma | D014141 | A71 | — | — | 1 | 2 | — | 3 | |
| Yaws | D015001 | EFO_0007548 | A66 | — | 1 | 1 | 1 | — | 3 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 2 | 5 | 1 | — | 1 | 8 |
| Pediculus | D010374 | 1 | 1 | 5 | — | — | 7 | ||
| Strongyloidiasis | D013322 | EFO_0007501 | B78 | — | — | 5 | — | 1 | 6 |
| Infections | D007239 | EFO_0000544 | — | 3 | 4 | — | 1 | 6 | |
| Trichuriasis | D014257 | EFO_0007524 | B79 | — | 3 | 3 | — | 1 | 5 |
| Lice infestations | D010373 | B85.2 | 1 | — | 1 | — | 2 | 4 | |
| Ascariasis | D001196 | EFO_0007154 | B77 | — | 1 | 2 | — | 1 | 3 |
| Hookworm infections | D006725 | EFO_0007314 | B76 | — | 1 | 2 | — | 1 | 3 |
| Dengue | D003715 | A90 | — | 1 | 1 | — | — | 1 | |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | 2 | 2 | — | — | — | 3 | |
| Helminthiasis | D006373 | EFO_1001342 | B65-B83 | — | 1 | — | — | 2 | 3 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | 1 | 2 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | 2 | 2 | — | — | — | 2 |
| Poisoning | D011041 | EFO_0008546 | T65.91 | 1 | 1 | — | — | 1 | 2 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 2 | — | — | — | 2 |
| Neoplasms | D009369 | C80 | — | 1 | — | — | — | 1 | |
| Wounds and injuries | D014947 | T14.8 | — | 1 | — | — | — | 1 | |
| Ocular onchocerciasis | D015827 | EFO_0007398 | B73 | — | 1 | — | — | — | 1 |
| Severe dengue | D019595 | A91 | — | 1 | — | — | — | 1 |
Show 5 more
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | — | 3 | 3 |
| Bacterial infections | D001424 | A49 | — | — | — | — | 1 | 1 | |
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | — | — | 1 | 1 | |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 1 | 1 |
| Pruritus | D011537 | HP_0000989 | L29 | — | — | — | — | 1 | 1 |
| Abdominal pain | D015746 | R10.9 | — | — | — | — | 1 | 1 | |
| Lymphedema | D008209 | Q82.0 | — | — | — | — | 1 | 1 | |
| Mansonelliasis | D008368 | EFO_0007357 | B74.4 | — | — | — | — | 1 | 1 |
| Respiratory tract infections | D012141 | J06.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | IVERMECTIN |
| INN | ivermectin |
| Description | Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, today it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications.
|
| Classification | Small molecule |
| Drug class | antiparasitics (ivermectin type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 70288-86-7 |
| RxCUI | 6069 |
| ChEMBL ID | CHEMBL1200633 |
| ChEBI ID | — |
| PubChem CID | 9812710 |
| DrugBank | DB00602 |
| UNII ID | 8883YP2R6D (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
P2RX4
P2RX4
CHRNA7
CHRNA7
P2RX7
P2RX7
Organism
Homo sapiens
Gene name
P2RX4
Gene synonyms
NCBI Gene ID
Protein name
P2X purinoceptor 4
Protein synonyms
ATP receptor, ATP-gated cation channel protein, P2X receptor, subunit 4, Purinergic receptor, purinergic receptor P2X, ligand gated ion channel, 4, purinergic receptor P2X4, purinoceptor P2X4
Uniprot ID
Mouse ortholog
P2rx4 (18438)
P2X purinoceptor 4 (Q9JJX6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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53,235 adverse events reported
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