Itacitinib
Itacitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK1. In addition, it is known to target tyrosine-protein kinase JAK2.
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Clinical Trials
53 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 4 | 3 | — | — | — | 5 | |
| Non-small-cell lung carcinoma | D002289 | — | 4 | — | — | — | 4 | ||
| Primary myelofibrosis | D055728 | D47.4 | — | 4 | — | — | — | 4 | |
| Myelodysplastic syndromes | D009190 | D46 | 1 | 2 | — | — | — | 3 | |
| Hodgkin disease | D006689 | C81 | 2 | 2 | — | — | — | 3 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 2 |
| Hematologic neoplasms | D019337 | 1 | 1 | — | — | — | 2 | ||
| Lung neoplasms | D008175 | C34.90 | 2 | 1 | — | — | — | 2 | |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 1 | — | — | — | 2 |
| Myeloid leukemia acute | D015470 | C92.0 | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | 2 | — | — | — | — | 2 | ||
| Renal cell carcinoma | D002292 | 1 | — | — | — | — | 1 | ||
| Colorectal neoplasms | D015179 | 1 | — | — | — | — | 1 | ||
| Endometrial neoplasms | D016889 | EFO_0004230 | 1 | — | — | — | — | 1 | |
| Head and neck neoplasms | D006258 | 1 | — | — | — | — | 1 | ||
| Prolymphocytic leukemia t-cell | D015461 | C91.6 | 1 | — | — | — | — | 1 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 1 | — | — | — | — | 1 | |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | 1 | — | — | — | — | 1 | ||
| Chondrosarcoma | D002813 | 1 | — | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ITACITINIB |
| INN | itacitinib |
| Description | Itacitinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK1. In addition, it is known to target tyrosine-protein kinase JAK2. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors; janus kinase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(C2CCN(C(=O)c3ccnc(C(F)(F)F)c3F)CC2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 1334298-90-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3622820 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 19J3781LPM (ChemIDplus, GSRS) |
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169 adverse events reported
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