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Isradipine
Dynacirc (isradipine) is a small molecule pharmaceutical. Isradipine was first approved as Dynacirc on 1990-12-20. It is used to treat hypertension and variant angina pectoris in the USA. It is known to target voltage-dependent L-type calcium channel subunit alpha-1D, voltage-dependent L-type calcium channel subunit alpha-1F, voltage-dependent L-type calcium channel subunit alpha-1S, and voltage-dependent L-type calcium channel subunit alpha-1C.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Isradipine
Tradename
Company
Number
Date
Products
DYNACIRC CRGSKN-020336 DISCN1994-06-01
2 products, RLD
DYNACIRCSmithkline BeechamN-019546 DISCN1990-12-20
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
isradipineANDA2023-06-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
variant angina pectoris—D000788I20.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C08: Calcium channel blockers
— C08C: Selective calcium channel blockers with mainly vascular effects
— C08CA: Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects
— C08CA03: Isradipine
HCPCS
No data
Clinical
Clinical Trials
44 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Invasive hydatidiform moleD002820D39.2———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Invasive fungal infectionsD000072742——2—13
AspergillosisD001228EFO_0007157B44——3——3
Myeloid leukemia acuteD015470C92.0—21——2
CandidemiaD058387EFO_1001282——1——1
Invasive candidiasisD058365EFO_1001283B37——1——1
MycosesD009181B35-B49——1——1
Sars-cov-2D000086402——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Invasive pulmonary aspergillosisD055744B44.0—2——13
MucormycosisD009091EFO_0007380B46.5—1——12
Hematologic neoplasmsD01933711———2
Myeloproliferative disordersD009196D47.1—1———1
Myelodysplastic syndromesD009190D46—1———1
NeutropeniaD009503D70—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—25————25
PharmacokineticsD0105993————3
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameISRADIPINE
INNisradipine
Description
Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.
Classification
Small molecule
Drug classphenylpyridine vasodilators; tricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12
Identifiers
PDB—
CAS-ID75695-93-1
RxCUI33910
ChEMBL IDCHEMBL1648
ChEBI ID—
PubChem CID3784
DrugBankDB00270
UNII IDYO1UK1S598 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CACNA1D
CACNA1D
CACNA1F
CACNA1F
CACNA1S
CACNA1S
CACNA1C
CACNA1C
Organism
Homo sapiens
Gene name
CACNA1D
Gene synonyms
CACH3, CACN4, CACNL1A2, CCHL1A2
NCBI Gene ID
776
Protein name
voltage-dependent L-type calcium channel subunit alpha-1D
Protein synonyms
calcium channel, L type, alpha-1 polypeptide, Calcium channel, L type, alpha-1 polypeptide, isoform 2, calcium channel, neuroendocrine/brain-type, alpha 1 subunit, calcium channel, voltage-dependent, L type, alpha 1D subunit, voltage-gated calcium channel alpha 1 subunit, voltage-gated calcium channel alpha subunit Cav1.3, Voltage-gated calcium channel subunit alpha Cav1.3
Uniprot ID
Q01668
Mouse ortholog
Cacna1d (12289)
voltage-dependent L-type calcium channel subunit alpha-1D (Q99246)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,863 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,366 adverse events reported
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