Ispinesib
Ispinesib is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 2 |
| Prostatic neoplasms | D011471 | C61 | — | 1 | — | — | — | 1 | |
| Renal cell carcinoma | D002292 | — | 1 | — | — | — | 1 | ||
| Colonic neoplasms | D003110 | C18 | — | 1 | — | — | — | 1 | |
| Rectal neoplasms | D012004 | — | 1 | — | — | — | 1 | ||
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 1 | — | — | — | 1 |
| Melanoma | D008545 | — | 1 | — | — | — | 1 | ||
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | — | 1 | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 4 | — | — | — | — | 4 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 3 | — | — | — | — | 3 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 2 | — | — | — | — | 2 | |
| Burkitt lymphoma | D002051 | C83.7 | 2 | — | — | — | — | 2 | |
| Lymphomatoid granulomatosis | D008230 | C83.8 | 2 | — | — | — | — | 2 | |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 1 | — | — | — | — | 1 | |
| Hodgkin disease | D006689 | C81 | 1 | — | — | — | — | 1 | |
| B-cell lymphoma marginal zone | D018442 | C88.4 | 1 | — | — | — | — | 1 | |
| Follicular lymphoma | D008224 | C82 | 1 | — | — | — | — | 1 | |
| Mantle-cell lymphoma | D020522 | C83.1 | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ISPINESIB |
| INN | ispinesib |
| Description | N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide is a member of benzamides. |
| Classification | Small molecule |
| Drug class | kinesin inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(C(=O)N(CCCN)[C@@H](c2nc3cc(Cl)ccc3c(=O)n2Cc2ccccc2)C(C)C)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 336113-53-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL228814 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | BKT5F9C2NI (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Trends
PubMed Central
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Additional graphs summarizing 302 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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25 adverse events reported
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