Isocarboxazid
Marplan (isocarboxazid) is a small molecule pharmaceutical. Isocarboxazid was first approved as Marplan on 1982-01-01. It is used to treat depressive disorder in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Marplan
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Isocarboxazid
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MARPLAN | VALIDUS PHARMS INC | N-011961 RX | 1982-01-01 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| marplan | New Drug Application | 2020-01-14 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| depressive disorder | EFO_1002014 | D003866 | F32.A |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
562 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | 10 | 14 | 35 | 39 | 81 | 173 |
| Anemia | D000740 | EFO_0004272 | D64.9 | 6 | 21 | 36 | 29 | 51 | 137 |
| Iron deficiencies | D000090463 | E61.1 | 1 | 5 | 8 | 10 | 31 | 54 | |
| Chronic renal insufficiency | D051436 | N18 | 3 | 1 | 9 | 11 | 4 | 28 | |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 2 | 5 | 8 | 4 | 18 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | 2 | 2 | 7 | 1 | 13 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | 1 | 1 | 4 | 5 | — | 11 | |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | — | 2 | 7 | 9 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | 1 | — | 2 | 4 | 7 |
| Colorectal neoplasms | D015179 | — | 1 | 1 | 2 | 2 | 6 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 5 | — | 2 | — | 4 | 11 | ||
| Neoplasms | D009369 | C80 | — | 2 | 3 | — | 1 | 6 | |
| Iron overload | D019190 | 1 | — | 1 | — | 4 | 6 | ||
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 2 | — | 4 | 6 |
| Child development | D002657 | — | — | 1 | — | 3 | 4 | ||
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | 1 | — | 2 | 3 |
| Hemochromatosis | D006432 | EFO_1000642 | E83.11 | — | 1 | 1 | — | 1 | 3 |
| Crohn disease | D003424 | EFO_0000384 | K50 | — | 1 | 1 | — | 1 | 3 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | 2 | — | 1 | 3 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 1 | 2 | — | — | 3 |
Show 34 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Replacement arthroplasty knee | D019645 | — | 1 | — | — | 4 | 5 | ||
| Chronic disease | D002908 | — | 1 | — | — | 1 | 2 | ||
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | 1 | — | — | 1 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | 1 | — | — | 1 | 2 | ||
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | 1 | — | — | — | 2 |
| Wounds and injuries | D014947 | T14.8 | — | 1 | — | — | 1 | 2 | |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 1 | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | — | — | — | 2 |
| Critical illness | D016638 | — | 1 | — | — | 1 | 2 | ||
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Iron metabolism disorders | D019189 | E83.1 | 1 | — | — | — | 1 | 2 | |
| Thalassemia | D013789 | EFO_1001996 | D56 | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | 1 | — | — | — | — | 1 | ||
| Ductal carcinoma breast | D018270 | 1 | — | — | — | — | 1 | ||
| Intraductal carcinoma noninfiltrating | D002285 | D05.1 | 1 | — | — | — | — | 1 | |
| Deficiency diseases | D003677 | EFO_1001067 | E63 | 1 | — | — | — | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | 1 | — | — | — | — | 1 | ||
| Coronary disease | D003327 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | — | — | — | — | 4 | 4 | ||
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 4 | 4 |
| Coronary artery disease | D003324 | I25.1 | — | — | — | — | 3 | 3 | |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 3 | 3 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 2 | 2 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | — | — | — | — | 2 | 2 |
| Growth disorders | D006130 | — | — | — | — | 2 | 2 | ||
| Infections | D007239 | EFO_0000544 | — | — | — | — | 2 | 2 | |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | — | — | 2 | 2 |
| Birth weight | D001724 | EFO_0004344 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ISOCARBOXAZID |
| INN | isocarboxazid |
| Description | 5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide is a member of benzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C(=O)NNCc2ccccc2)no1 |
Identifiers
| PDB | — |
| CAS-ID | 59-63-2 |
| RxCUI | 6011 |
| ChEMBL ID | CHEMBL1201168 |
| ChEBI ID | — |
| PubChem CID | 3759 |
| DrugBank | DB01247 |
| UNII ID | 34237V843T (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 573 documents
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Safety
Black-box Warning
Black-box warning for: Marplan
Adverse Events
Top Adverse Reactions
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6,748 adverse events reported
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