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Ipratropium
Atrovent, Combivent (ipratropium) is a small molecule pharmaceutical. Ipratropium was first approved as Atrovent on 1986-12-29. It is used to treat allergic rhinitis perennial, bronchial spasm, bronchitis, pulmonary emphysema, and vasomotor rhinitis in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M4.
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Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Atrovent (generic drugs available since 2001-01-26)
Combinations
Combivent (generic drugs available since 2001-01-26, discontinued: Duoneb)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Albuterol sulfate
+
Ipratropium bromide
Tradename
Company
Number
Date
Products
COMBIVENT RESPIMATBoehringer IngelheimN-021747 RX2011-10-07
1 products, RLD, RS
Show 2 discontinued
Ipratropium bromide
Tradename
Company
Number
Date
Products
ATROVENT HFABoehringer IngelheimN-021527 RX2004-11-27
1 products, RLD, RS
Show 4 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
atroventNew Drug Application2023-06-07
combivent respimatNew Drug Application2022-01-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
bronchial spasm—D001986—
bronchitis—D001991J40
pulmonary emphysema—D011656J43
vasomotor rhinitisEFO_0007533D012223J30.0
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Albuterol Sulfate / Ipratropium Bromide, Combivent Respimat, Boehringer Ingelheim
87333412030-10-16DP
78372352028-03-13DP
90279672027-03-31DP
73963412026-10-10DP
78962642025-05-26DP
72844742024-08-26DP
Ipratropium Bromide, Atrovent Hfa, Boehringer Ingelheim
84744472030-01-17DP
ATC Codes
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AX: Other nasal preparations in atc
— R01AX03: Ipratropium bromide
— R03: Drugs for obstructive airway diseases
— R03A: Adrenergics, inhalants
— R03AL: Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
— R03AL01: Fenoterol and ipratropium bromide
— R03AL02: Salbutamol and ipratropium bromide
— R03B: Other drugs for obstructive airway diseases, inhalants in atc
— R03BB: Anticholinergics inhalants for obstructive airway diseases
— R03BB01: Ipratropium bromide
HCPCS
Code
Description
J7620
Albuterol, up to 2.5 mg and ipratropium bromide, up to 0.5 mg, fda-approved final product, non-compounded, administered through dme
J7644
Ipratropium bromide, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per milligram
J7645
Ipratropium bromide, inhalation solution, compounded product, administered through dme, unit dose form, per milligram
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameIPRATROPIUM
INNipratropium bromide
Description
Ipratropium bromide is the anhydrous form of the bromide salt of ipratropium. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstructive pulmonary disease and acute asthma. It has a role as a bronchodilator agent, a muscarinic antagonist and an antispasmodic drug. It contains an ipratropium.
Classification
Small molecule
Drug classquaternary ammonium derivatives; atropine derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)[N+]1(C)[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2
Identifiers
PDB—
CAS-ID22254-24-6
RxCUI203212
ChEMBL IDCHEMBL1621597
ChEBI ID—
PubChem CID657308
DrugBankDB00332
UNII IDVJV4X1P2Z1 (ChemIDplus, GSRS)
Target
Agency Approved
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM3
Gene synonyms
NCBI Gene ID
1131
Protein name
muscarinic acetylcholine receptor M3
Protein synonyms
acetylcholine receptor, muscarinic 3, m3 muscarinic receptor
Uniprot ID
Q9HB60
Mouse ortholog
Chrm3 (12671)
muscarinic acetylcholine receptor M3 (Q9ERZ3)
Alternate
CHRM2
CHRM2
CHRM5
CHRM5
CHRM1
CHRM1
CHRM4
CHRM4
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (E9Q9P0)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2 adverse events reported
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