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Intepirdine
Intepirdine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against 5-hydroxytryptamine receptor 6.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alzheimer diseaseD000544EFO_0000249F03152——8
DementiaD003704F03—31——3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G20—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameINTEPIRDINE
INNintepirdine
Description
Intepirdine (INN; developmental codes SB-742457, RVT-101) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects. It was under development by GlaxoSmithKline for the treatment of Alzheimer's disease and demonstrated some preliminary efficacy in phase II clinical trials. GSK chose not to continue development and sold the rights to Axovant Sciences for $5 million in December 2014.
Classification
Small molecule
Drug classserotonin 5-HT6 receptor inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=S(=O)(c1ccccc1)c1cnc2c(N3CCNCC3)cccc2c1
Identifiers
PDB—
CAS-ID607742-69-8
RxCUI—
ChEMBL IDCHEMBL1083390
ChEBI ID—
PubChem CID11256720
DrugBankDB12680
UNII ID2IOB2M82HY (ChemIDplus, GSRS)
Target
Agency Approved
HTR6
HTR6
Organism
Homo sapiens
Gene name
HTR6
Gene synonyms
NCBI Gene ID
3362
Protein name
5-hydroxytryptamine receptor 6
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled, Serotonin receptor 6
Uniprot ID
Q5TGZ1
Mouse ortholog
Htr6 (15565)
5-hydroxytryptamine receptor 6 (Q9R1C8)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 65 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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