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Inositol
Inositol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target anoctamin-1, two pore channel protein 1, inositol polyphosphate-5-phosphatase A, inositol 1,4,5-trisphosphate receptor type 1, mucolipin-2, inositol 1,4,5-trisphosphate receptor type 2, inositol 1,4,5-trisphosphate receptor type 3, mucolipin-3, two pore channel protein 2, and mucolipin-1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A11: Vitamins
A11H: Other plain vitamin preparations in atc
A11HA: Other plain vitamin preparations in atc
A11HA07: Inositol
C: Cardiovascular system drugs
C04: Peripheral vasodilators
C04A: Peripheral vasodilators
C04AC: Nicotinic acid and derivatives, peripheral vasodilators
C04AC03: Inositol nicotinate
HCPCS
No data
Clinical
Clinical Trials
85 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Polycystic ovary syndromeD011085EFO_0000660E28.214231524
Gestational diabetesD016640HP_0009800O24.41910
InfertilityD007246EFO_000054521327
Insulin resistanceD007333EFO_00026142125
Metabolic syndromeD024821EFO_0000195E88.811113
ObesityD009765EFO_0001073E66.9112
Ovulation inductionD01006211
Pediatric obesityD06376611
Yin deficiencyD01671011
Mood disordersD019964EFO_0004247F30-F3911
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Retinopathy of prematurityD012178EFO_1001158H35.1213
Female infertilityD007247EFO_0008560N97112
LeiomyomaD007889HP_0000131D25112
Type 1 diabetes mellitusD003922EFO_0001359E1011
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.91112
Glucose intoleranceD018149HP_0000833R73.03112
HyperandrogenismD017588112
Bronchopulmonary dysplasiaD001997P27.822
AnovulationD00085811
PeriodontitisD010518EFO_0000649K05.311
HumansD006801STY/T016111
CryopreservationD015925111
Anxiety disordersD001008EFO_0006788F41.1111
AnxietyD001007EFO_0005230F41.1111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Neural tube defectsD009436HP_0002144Q00.0112
Lung neoplasmsD008175C34.9011
Precancerous conditionsD01123011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HirsutismD006628HP_0001007L68.022
Menstruation disturbancesD008599HP_0400007N91.522
EunuchismD005058EFO_0007266E29.111
DepressionD003863F33.911
Type 2 diabetes mellitusD003924EFO_0001360E1111
OligospermiaD009845N46.111
AsthenozoospermiaD05362711
PregnancyD011247EFO_0002950Z33.111
Pre-eclampsiaD011225EFO_0000668O1411
Premature birthD047928EFO_0003917O6011
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameINOSITOL
INNinositol
Description
Myo-inositol is an inositol having myo- configuration. It has a role as a member of compatible osmolytes, a nutrient, an EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor, a human metabolite, a Daphnia magna metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
Identifiers
PDB
CAS-ID87-89-8
RxCUI
ChEMBL IDCHEMBL1222251
ChEBI ID17268
PubChem CID892
DrugBankDB03106
UNII ID4L6452S749 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ANO1
ANO1
TPCN1
TPCN1
INPP5A
INPP5A
ITPR1
ITPR1
MCOLN2
MCOLN2
ITPR2
ITPR2
ITPR3
ITPR3
MCOLN3
MCOLN3
TPCN2
TPCN2
MCOLN1
MCOLN1
Organism
Homo sapiens
Gene name
ANO1
Gene synonyms
DOG1, ORAOV2, TAOS2, TMEM16A
NCBI Gene ID
Protein name
anoctamin-1
Protein synonyms
anoctamin 1, calcium activated chloride channel, Ca2+-activated Cl- channel, calcium activated chloride channel, Discovered on gastrointestinal stromal tumors protein 1, oral cancer overexpressed 2, Oral cancer overexpressed protein 2, Transmembrane protein 16A, transmembrane protein 16A (eight membrane-spanning domains), Tumor-amplified and overexpressed sequence 2
Uniprot ID
Mouse ortholog
Ano1 (101772)
anoctamin-1 (Q99JK1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 120,153 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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16 adverse events reported
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