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Indisulam
Indisulam is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target carbonic anhydrase 7, carbonic anhydrase 1, and carbonic anhydrase 12.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5022
Colorectal neoplasmsD01517922
Neoplasm metastasisD009362EFO_000970811
LeukemiaD007938C9511
Stomach neoplasmsD013274EFO_0003897C16111
Renal cell carcinomaD00229211
Kidney neoplasmsD007680EFO_0003865C6411
MelanomaD00854511
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8033
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameINDISULAM
INNindisulam
Description
Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a chloroindole, a sulfonamide and an organochlorine compound.
Classification
Small molecule
Drug classantineoplastics, apoptosis inducing sulfonamide
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)c1ccc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)cc1
Identifiers
PDB
CAS-ID165668-41-7
RxCUI
ChEMBL IDCHEMBL77517
ChEBI ID
PubChem CID216468
DrugBankDB06370
UNII IDWJ98J3NM90 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA7
CA7
CA1
CA1
CA12
CA12
Organism
Homo sapiens
Gene name
CA7
Gene synonyms
NCBI Gene ID
Protein name
carbonic anhydrase 7
Protein synonyms
CA-VII, Carbonate dehydratase VII, Carbonic anhydrase VII, carbonic dehydratase VII
Uniprot ID
Mouse ortholog
Car7 (12354)
carbonic anhydrase 7 (Q9ERQ8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 338 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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