Indantadol
Indantadol is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 2 | — | — | — | 2 | |
| Cough | D003371 | HP_0012735 | R05 | — | 1 | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | INDANTADOL |
| INN | indantadol |
| Description | Indantadol (CHF-3381, V-3381) is a drug which was formerly being investigated as an anticonvulsant and neuroprotective and is now under development for the treatment of neuropathic pain and chronic cough in Europe by Vernalis and Chiesi. It acts as a competitive, reversible, and non-selective monoamine oxidase inhibitor, and as a low affinity, non-competitive NMDA receptor antagonist. A pilot study of indantadol for chronic cough was initiated in October 2009 and in April 2010 it failed to achieve significant efficacy in neuropathic pain in phase IIb clinical trials.
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| Classification | Small molecule |
| Drug class | analgesics (mixed opiate receptor agonists/antagonists) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)CNC1Cc2ccccc2C1 |
Identifiers
| PDB | — |
| CAS-ID | 202844-10-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707400 |
| ChEBI ID | — |
| PubChem CID | 10192617 |
| DrugBank | DB12664 |
| UNII ID | Z3867B9SQP (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
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