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Imipramine
Janimine, Pramine, Presamine, Tofranil, Tofranil-pm (imipramine) is a small molecule pharmaceutical. Imipramine was first approved as Janimine on 1982-01-01. It is used to treat attention deficit disorder with hyperactivity, depressive disorder, enuresis, pain, and panic disorder amongst others in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter. In addition, it is known to target potassium voltage-gated channel subfamily H member 1, muscarinic acetylcholine receptor M2, G protein-activated inward rectifier potassium channel 2, and G protein-activated inward rectifier potassium channel 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
behavior and behavior mechanismsD001520
psychological phenomenaD011579
mental disordersD001523
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Imipramine hydrochloride
Tradename
Company
Number
Date
Products
JANIMINEAbbott BiotherapeuticsN-017895 DISCN1982-01-01
3 products
TOFRANILNovartisN-011838 DISCN1982-01-01
1 products
PRESAMINESanofiN-011836 DISCN1982-01-01
3 products
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Imipramine pamoate
Tradename
Company
Number
Date
Products
TOFRANIL-PMMallinckrodtN-017090 DISCN1982-01-01
4 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
imipramine hydrochlorideANDA2023-05-01
tofranilANDA2016-12-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
attention deficit disorder with hyperactivityEFO_0003888D001289F90
depressive disorderEFO_1002014D003866F32.A
enuresis—D004775R32
painEFO_0003843D010146R52
panic disorderEFO_0004262D016584F41.0
psychotic affective disorders—D000341F39
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AA: Non-selective monoamine reuptake inhibitors
— N06AA02: Imipramine
— N06AA03: Imipramine oxide
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameIMIPRAMINE
INNimipramine
Description
Imipramine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom. It has a role as an adrenergic uptake inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an antidepressant. It derives from a hydride of a 5H-dibenzo[b,f]azepine.
Classification
Small molecule
Drug classantidepressants (imipramine type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCCN1c2ccccc2CCc2ccccc21
Identifiers
PDB2Q72
CAS-ID50-49-7
RxCUI5691
ChEMBL IDCHEMBL11
ChEBI ID47499
PubChem CID3696
DrugBankDB00458
UNII IDOGG85SX4E4 (ChemIDplus, GSRS)
Target
Agency Approved
SLC6A4
SLC6A4
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
6532
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Q5EE02
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
KCNH1
KCNH1
CHRM2
CHRM2
KCNJ6
KCNJ6
KCNJ5
KCNJ5
Organism
Homo sapiens
Gene name
KCNH1
Gene synonyms
EAG, EAG1
NCBI Gene ID
3756
Protein name
potassium voltage-gated channel subfamily H member 1
Protein synonyms
EAG channel 1, ether-a-go-go 1, Ether-a-go-go potassium channel 1, ether-a-go-go, Drosophila, homolog of, h-eag, hEAG1, potassium channel, voltage gated eag related subfamily H, member 1, potassium voltage-gated channel, subfamily H (eag-related), member 1, Voltage-gated potassium channel subunit Kv10.1
Uniprot ID
O95259
Mouse ortholog
Kcnh1 (16510)
potassium voltage-gated channel subfamily H member 1 (Q60603)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 15,723 documents
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Safety
Black-box Warning
Black-box warning for: Imipramine hydrochloride, Tofranil
Adverse Events
Top Adverse Reactions
Mock data
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36 adverse events reported
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