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Iclaprim
Iclaprim is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target dihydrofolate reductase.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01E: Sulfonamides and trimethoprim antibacterials for systemic use
— J01EA: Trimethoprim and derivatives, systemic antibacterials
— J01EA03: Iclaprim
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Soft tissue infectionsD018461——2——2
Bacterial skin diseasesD017192——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atopic dermatitisD003876EFO_0000274L2011———1
Ventilator-associated pneumoniaD053717EFO_1001865J95.851—1———1
Healthcare-associated pneumoniaD000077299—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameICLAPRIM
INNiclaprim
Description
5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]pyrimidine-2,4-diamine is an aminopyrimidine that is 5-methylpyrimidine-2,4-diamine in which one of the hydrogens of the methyl group has been replaced by a 2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl group. It is an aminopyrimidine, a member of chromenes and a member of cyclopropanes.
Classification
Small molecule
Drug classantibacterials (trimethoprim type), dihydrofolate reductase (DHFR) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(Cc2cnc(N)nc2N)c2c(c1OC)OC(C1CC1)C=C2
Identifiers
PDB—
CAS-ID192314-93-5
RxCUI—
ChEMBL IDCHEMBL134561
ChEBI ID—
PubChem CID213043
DrugBankDB06358
UNII ID42445HUU0O (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
DHFR
DHFR
Organism
Homo sapiens
Gene name
DHFR
Gene synonyms
NCBI Gene ID
1719
Protein name
dihydrofolate reductase
Protein synonyms
Uniprot ID
Q6IRW8
Mouse ortholog
Dhfr (13361)
dihydrofolate reductase (Q61579)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 189 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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