Ibudilast
Ibudilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, and cAMP-specific 3',5'-cyclic phosphodiesterase 4C. In addition, it is known to target cGMP-specific 3',5'-cyclic phosphodiesterase, cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, and macrophage migration inhibitory factor.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
22 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | 1 | 3 | 1 | — | — | 3 |
| Spinal cord diseases | D013118 | HP_0002196 | G95.9 | — | — | 1 | — | — | 1 |
| Covid-19 | D000086382 | U07.1 | — | 1 | 1 | — | — | 1 | |
| Post-acute covid-19 syndrome | D000094024 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 1 | 3 | — | — | — | 4 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 2 | — | — | — | 2 |
| Chronic progressive multiple sclerosis | D020528 | — | 1 | — | — | — | 1 | ||
| Glioblastoma | D005909 | EFO_0000515 | 1 | 1 | — | — | — | 1 | |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | — | 1 | — | — | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | — | 1 |
| Secondary headache disorders | D051271 | 1 | 1 | — | — | — | 1 | ||
| Diabetic neuropathies | D003929 | EFO_1000783 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 | ||
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | — | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | IBUDILAST |
| INN | ibudilast |
| Description | Ibudilast is a pyrazolopyridine. |
| Classification | Small molecule |
| Drug class | antiasthmatics/antiallergics (not acting primarily as antihistamines); vasodilators (undefined group) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C(=O)c1c(C(C)C)nn2ccccc12 |
Identifiers
| PDB | 4GRQ |
| CAS-ID | 50847-11-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19449 |
| ChEBI ID | — |
| PubChem CID | 3671 |
| DrugBank | DB05266 |
| UNII ID | M0TTH61XC5 (ChemIDplus, GSRS) |
Target
Agency Approved
PDE4A
PDE4A
PDE4B
PDE4B
PDE4C
PDE4C
Organism
Homo sapiens
Gene name
PDE4A
Gene synonyms
DPDE2
NCBI Gene ID
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Protein synonyms
DPDE2, PDE46, phosphodiesterase 4A, cAMP-specific (dunce, phosphodiesterase E2 dunce homolog, Drosophila, phosphodiesterase isozyme 4
Uniprot ID
Mouse ortholog
Pde4a (18577)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (O89084)
Alternate
PDE5A
PDE5A
PDE3A
PDE3A
MIF
MIF
Organism
Homo sapiens
Gene name
PDE5A
Gene synonyms
PDE5
NCBI Gene ID
Protein name
cGMP-specific 3',5'-cyclic phosphodiesterase
Protein synonyms
CGB-PDE, cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase, cGMP-binding cGMP-specific phosphodiesterase, cGMP-specific phosphodiesterase PDE5A2, cGMP-specific phosphodiesterase type 5A, phosphodiesterase 5A, cGMP-specific, phosphodiesterase isozyme 5
Uniprot ID
Mouse ortholog
Pde5a (242202)
cGMP-specific 3',5'-cyclic phosphodiesterase (Q8CG03)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 995 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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53 adverse events reported
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