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Ibodutant
Ibodutant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target substance-K receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Irritable bowel syndromeD043183EFO_0000555K58—23——5
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameIBODUTANT
INNibodutant
Description
Ibodutant was a candidate drug for irritable bowel syndrome diarrhea, developed by The Menarini Group. As of March 2015, it underwent a multicentre double blind efficacy clinical study. Ibodutant selectively blocks the tachykinin receptor NK2, with blockade practically complete in nanomolar concentrations. A phase 2 trial in Europe (the IRIS-2 trial) completed in May 2012 with positive results. A 52-week phase 3 study was terminated as of 2015 because of low response and negative results of study NAK-06.
Classification
Small molecule
Drug classtachykinin (neurokinin) receptor antagonists: NK2 receptor antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1
Identifiers
PDB—
CAS-ID522664-63-7
RxCUI—
ChEMBL IDCHEMBL266125
ChEBI ID—
PubChem CID11527495
DrugBankDB12042
UNII ID1H7RSQ28BJ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TACR2
TACR2
Organism
Homo sapiens
Gene name
TACR2
Gene synonyms
NK2R, NKNAR, TAC2R
NCBI Gene ID
6865
Protein name
substance-K receptor
Protein synonyms
neurokinin 2 receptor, Neurokinin A receptor, neurokinin B receptor, NK-2 receptor, NK-2R, seven transmembrane helix receptor, Tachykinin receptor 2
Uniprot ID
Q9UDE7
Mouse ortholog
Tacr2 (21337)
substance-K receptor (P30549)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 37 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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