Eskata, Sibnayal(hydrogen peroxide)
Eskata, Sibnayal (hydrogen peroxide) is a small molecule pharmaceutical. Hydrogen peroxide was first approved as Eskata on 2017-12-14. It is used to treat surgical wound infection in the USA. It has been approved in Europe to treat renal tubular acidosis. It is known to target transient receptor potential cation channel subfamily M member 2 and transient receptor potential cation channel subfamily A member 1.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
| hereditary congenital and neonatal diseases and abnormalities | D009358 |
| nutritional and metabolic diseases | D009750 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydrogen peroxide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ESKATA | Aclaris Therapeutics | N-209305 DISCN | 2017-12-14 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| eskata | New Drug Application | 2019-03-27 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| surgical wound infection | — | D013530 | — |
Agency Specific
FDA
EMA
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB02: Hydrogen peroxide
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AX: Other antiseptics and disinfectants in atc
— D08AX01: Hydrogen peroxide
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX25: Hydrogen peroxide
S: Sensory organ drugs
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA06: Hydrogen peroxide
HCPCS
No data
Clinical
Clinical Trials
78 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | — | 2 | — | 3 | 3 | 8 | |
| Seborrheic keratosis | D017492 | EFO_0005584 | L82 | 1 | 4 | 3 | 1 | — | 8 |
| Tooth bleaching | D014073 | 1 | — | 1 | 1 | 2 | 5 | ||
| Sars-cov-2 | D000086402 | — | — | — | 1 | — | 1 | ||
| Viral load | D019562 | — | — | — | 1 | — | 1 | ||
| Polymerase chain reaction | D016133 | OBI_0000415 | — | — | — | 1 | — | 1 | |
| Sensitivity and specificity | D012680 | — | — | — | 1 | — | 1 | ||
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gingivitis | D005891 | K05.10 | — | — | 1 | — | 2 | 3 | |
| Dentin sensitivity | D003807 | — | — | 1 | — | 2 | 3 | ||
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 1 | — | 1 | — | — | 2 |
| Surgical wound | D000072836 | — | — | 1 | — | — | 1 | ||
| Periodontal pocket | D010514 | EFO_1001393 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | — | 2 |
| Healthy volunteers/patients | — | — | 2 | — | — | — | 2 | ||
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | 1 | — | — | — | 1 |
| Warts | D014860 | B07 | — | 1 | — | — | — | 1 | |
| Squamous cell carcinoma | D002294 | — | 1 | — | — | — | 1 | ||
| Basal cell neoplasms | D018295 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wound healing | D014945 | GO_0042060 | 1 | — | — | — | 1 | 2 | |
| Dental caries | D003731 | EFO_0003819 | K02 | 1 | — | — | — | — | 1 |
| Peri-implantitis | D057873 | EFO_1001390 | 1 | — | — | — | — | 1 | |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Refractive errors | D012030 | EFO_0003908 | H52.7 | — | — | — | — | 5 | 5 |
| Tooth discoloration | D014075 | K03.6 | — | — | — | — | 3 | 3 | |
| Presbyopia | D011305 | H52.4 | — | — | — | — | 2 | 2 | |
| Disease susceptibility | D004198 | — | — | — | — | 1 | 1 | ||
| Myopia | D009216 | H52.1 | — | — | — | — | 1 | 1 | |
| Hyperopia | D006956 | H52.0 | — | — | — | — | 1 | 1 | |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 1 | 1 |
| Oxidative stress | D018384 | EFO_1001905 | — | — | — | — | 1 | 1 | |
| Coronavirus | D017934 | — | — | — | — | 1 | 1 | ||
| Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | HYDROGEN PEROXIDE |
| INN | — |
| Description | Peroxides is compounds of structure ROOR'. It has a role as an oxidising agent. It contains a peroxy group. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | OO |
Identifiers
| PDB | 1NG4 |
| CAS-ID | 7722-84-1 |
| RxCUI | 5499 |
| ChEMBL ID | CHEMBL71595 |
| ChEBI ID | 16240 |
| PubChem CID | 784 |
| DrugBank | DB11091 |
| UNII ID | — |
Target
Agency Approved
No data
Alternate
TRPM2
TRPM2
TRPA1
TRPA1
Organism
Homo sapiens
Gene name
TRPM2
Gene synonyms
EREG1, KNP3, LTRPC2, TRPC7
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily M member 2
Protein synonyms
Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, Transient receptor potential melastatin 2, TrpC7
Uniprot ID
Mouse ortholog
Trpm2 (28240)
transient receptor potential cation channel subfamily M member 2 (Q91YD4)
Variants
Clinical Variant
No data
Financial
Eskata - Aclaris Therapeutics
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 261,106 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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538 adverse events reported
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