Thrombin
Evicel, TachoSil, VeraSeal (thrombin) is an unknown pharmaceutical. Thrombin was first approved as Tachosil on 2004-06-08. It is used to treat hemorrhage in the USA. It has been approved in Europe to treat hemostasis and surgical hemostasis.
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FDA
EMA
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tachosil | Biologic Licensing Application | 2022-11-02 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hemorrhage | MP_0001914 | D006470 | R58 |
Agency Specific
FDA
EMA
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Patent Expiration
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Clinical
Clinical Trials
238 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 4 | 6 | 6 | 7 | 23 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | 1 | 1 | 1 | 6 | 8 |
| Hemostasis | D006487 | 1 | 2 | — | 3 | 2 | 7 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 2 | 1 | 3 | 6 |
| Surgical blood loss | D016063 | — | — | 1 | 1 | 3 | 5 | ||
| Anastomotic leak | D057868 | — | 1 | 1 | 2 | 1 | 5 | ||
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | 1 | — | — | 2 | 1 | 4 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | 1 | 2 | 3 |
| Lymphocele | D008210 | — | — | 2 | 1 | — | 3 | ||
| Uterine cervical neoplasms | D002583 | — | — | 1 | 2 | — | 3 |
Show 18 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pterygium | D011625 | H11.0 | 2 | 1 | 2 | — | 5 | 9 | |
| Replacement arthroplasty knee | D019645 | — | — | 2 | — | 2 | 4 | ||
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | 1 | — | 2 | 3 |
| Cerebrospinal fluid leak | D065634 | G96.0 | — | 1 | 2 | — | — | 3 | |
| Rectal fistula | D012003 | HP_0010447 | K60.3 | — | — | 3 | — | — | 3 |
| Wounds and injuries | D014947 | T14.8 | — | — | 2 | — | 1 | 3 | |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | 1 | — | 2 | 3 |
| Burns | D002056 | T30.0 | 1 | 2 | 1 | — | 1 | 3 | |
| Crohn disease | D003424 | EFO_0000384 | K50 | — | — | 1 | — | 1 | 2 |
| Cardiopulmonary bypass | D002315 | — | — | 1 | — | 1 | 2 |
Show 26 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative hemorrhage | D019106 | — | 2 | — | — | 1 | 3 | ||
| Seroma | D049291 | — | 1 | — | — | 1 | 2 | ||
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | 2 | 1 | — | — | — | 2 |
| Rotator cuff injuries | D000070636 | M75.1 | — | 2 | — | — | — | 2 | |
| Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | 1 | |
| Gallstones | D042882 | EFO_0004210 | — | 1 | — | — | — | 1 | |
| Pathologic processes | D010335 | — | 1 | — | — | — | 1 | ||
| Postoperative pain | D010149 | G89.18 | — | 1 | — | — | — | 1 | |
| Thromboembolism | D013923 | HP_0001907 | — | 1 | — | — | — | 1 | |
| Venus | D018536 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Corneal ulcer | D003320 | H16.0 | 1 | — | — | — | 1 | 2 | |
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 | ||
| Intraabdominal infections | D059413 | 1 | — | — | — | — | 1 | ||
| Intestinal fistula | D007412 | K63.2 | 1 | — | — | — | — | 1 | |
| Periodontal diseases | D010510 | K05.6 | 1 | — | — | — | — | 1 | |
| Periodontal pocket | D010514 | EFO_1001393 | 1 | — | — | — | — | 1 | |
| Periodontal attachment loss | D017622 | 1 | — | — | — | — | 1 | ||
| Abdominal hernia | D046449 | K46 | 1 | — | — | — | — | 1 | |
| Ventral hernia | D006555 | EFO_1001866 | K43 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | — | — | — | — | 3 | 3 | |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 2 | 2 | |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | — | — | — | 2 | 2 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | — | 2 | 2 |
| Disseminated intravascular coagulation | D004211 | HP_0005521 | D65 | — | — | — | — | 2 | 2 |
| Cataract | D002386 | EFO_0001059 | H26.9 | — | — | — | — | 1 | 1 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | — | 1 | 1 |
| Embolism and thrombosis | D016769 | — | — | — | — | 1 | 1 | ||
| Fibrosis | D005355 | — | — | — | — | 1 | 1 | ||
| Coronary disease | D003327 | — | — | — | — | 1 | 1 |
Show 33 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | THROMBIN |
| INN | thrombin |
| Description | Thrombin (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.
|
| Classification | Unknown |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >4UD9:H|Thrombin heavy chain
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVL
QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY
THVFRLKKWIQKVIDQFGE
>4UD9:I|Hirudin-2
GDFEEIPEE(TYS)LQ
>4UD9:L|Prothrombin
EADCGLRPLFEKKSLEDKTERELLESYI |
Identifiers
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
Identifier | Target mutation | Effect | Evaluation | Status |
|---|---|---|---|---|
| VCV000003520 | MTHFR, 665C>T, Ala222Val | drug response | 2021-10-21 | 2A |
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,919 adverse events reported
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