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Heparin
Calciparine, Embolex, Lipo-hepin, Liquaemin, Panheprin (heparin) is an unknown pharmaceutical. Heparin was first approved as Calciparine on 1982-01-01. It is used to treat cerebral infarction, coronary thrombosis, myocardial infarction, postoperative complications, and pulmonary embolism amongst others in the USA. The pharmaceutical is active against antithrombin-III. In addition, it is known to target epidermal growth factor receptor and receptor tyrosine-protein kinase erbB-4.
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COVID-19
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dihydroergotamine mesylate
+
Heparin sodium
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
EMBOLEXNovartisN-018885 DISCN1984-11-30
2 products
Hide discontinued
Heparin calcium
Tradename
Company
Number
Date
Products
CALCIPARINESanofiN-018237 DISCN1982-01-01
1 products
Hide discontinued
Heparin sodium
Tradename
Company
Number
Date
Products
HEPARIN SODIUM 20,000 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019952 RX1992-07-20
1 products, RLD, RS
HEPARIN SODIUM 25,000 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019952 RX1992-07-20
2 products, RLD, RS
HEPARIN SODIUM 1,000 UNITS IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERB. Braun MedicalN-019953 RX1992-07-20
1 products, RLD, RS
HEPARIN SODIUM 2,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERBaxterN-018609 RX2020-04-23
1 products
HEPARIN SODIUM 1,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERBaxterN-018609 RX1982-04-28
1 products
HEPARIN SODIUM 2,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERBaxterN-018609 RX1982-04-28
1 products
HEPARIN SODIUMFresenius KabiN-017029 RX2011-03-31
1 products, RLD, RS
HEPARIN SODIUM PRESERVATIVE FREEFresenius KabiN-017029 RX1986-04-28
2 products, RLD, RS
HEPARIN SODIUM IN PLASTIC CONTAINERFresenius KabiN-017029 RX1985-12-05
4 products, RLD, RS
HEPARIN SODIUMFresenius KabiN-017029 RX1982-01-01
3 products, RLD, RS
Show 12 marketed
Show 59 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
heparin sodiumANDA2023-04-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cerebral infarctionD002544I63
coronary thrombosisEFO_1000883D003328I21
myocardial infarctionEFO_0000612D009203I21
postoperative complicationsD011183
pulmonary embolismEFO_0003827D011655I26
thromboembolismHP_0001907D013923
thrombophlebitisHP_0004418D013924
unstable anginaEFO_1000985D000789I20.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
B01: Antithrombotic agents
B01A: Antithrombotic agents
B01AB: Heparin group antithrombotic drugs
B01AB01: Heparin
B01AB51: Heparin, combinations
B01AC: Platelet aggregation inhibitors excl. heparin
B01AC30: Platelet aggregation inhibitor combinations excl. heparin
C: Cardiovascular system drugs
C05: Vasoprotectives
C05B: Antivaricose therapy drugs
C05BA: Heparins or heparinoids for topical use
C05BA03: Heparin
C05BA53: Heparin, combinations
S: Sensory organ drugs
S01: Ophthalmologicals
S01X: Other ophthalmologicals in atc
S01XA: Other ophthalmologicals in atc
S01XA14: Heparin
HCPCS
Code
Description
B4216
Parenteral nutrition; additives (vitamins, trace elements, heparin, electrolytes), home mix, per day
E1520
Heparin infusion pump for hemodialysis
J1642
Injection, heparin sodium, (heparin lock flush), per 10 units
J1644
Injection, heparin sodium, per 1000 units
S2120
Low density lipoprotein (ldl) apheresis using heparin-induced extracorporeal ldl precipitation
S9336
Home infusion therapy, continuous anticoagulant infusion therapy (e.g., heparin), administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem
S9372
Home therapy; intermittent anticoagulant injection therapy (e.g., heparin); administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem (do not use this code for flushing of infusion devices with heparin to maintain patency)
Clinical
Clinical Trials
497 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Venous thrombosisD020246HP_0004936I82.402310101337
Covid-19D000086382U07.1412118632
Venous thromboembolismD054556EFO_0004286I7424115930
Pulmonary embolismD011655EFO_0003827I2622610222
ThrombosisD01392713421120
Coronary artery diseaseD003324I25.1518418
NeoplasmsD009369C802261616
Catheter-related infectionsD055499123612
Renal dialysisD006435EFO_0010690Z99.2223612
Chronic kidney failureD007676EFO_0003884N18.62362111
Show 66 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients91110
Septic shockD012772A48.33126
Critical illnessD0166382215
Cardiovascular diseasesD002318EFO_0000319I98235
Coronary artery bypassD001026EFO_0003776224
Colorectal neoplasmsD015179133
Proliferative vitreoretinopathyD018630EFO_100112933
Upper extremity deep vein thrombosisD0568242113
BurnsD002056T30.01123
Balloon angioplasty coronaryD015906EFO_0003951123
Show 30 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E102327
ObesityD009765EFO_0001073E66.91167
Urinary tract infectionsD014552EFO_0003103N39.0122
Intracranial aneurysmD002532EFO_0003870I67.1112
CataractD002386EFO_0001059H26.922
Spinal cord injuriesD013119EFO_100191911
Embolic strokeD00008326211
AlcoholismD000437EFO_0003829F10.111
Lower urinary tract symptomsD059411EFO_000800811
Iga vasculitisD011695EFO_1000965D69.0111
Show 12 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Antiphospholipid syndromeD016736EFO_0002689D68.61123
StomatitisD013280EFO_1001904K12.111
ThrombophlebitisD013924HP_000441811
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peripheral vascular diseasesD016491EFO_0003875I73.933
Peripheral arterial diseaseD058729EFO_000426522
Pancreatic neoplasmsD010190EFO_0003860C2522
Hyperlipoproteinemia type iD008072Orphanet_411E78.322
Insulin resistanceD007333EFO_000261422
Optical coherence tomographyD04162311
Cytokine release syndromeD000080424D89.8311
Undifferentiated connective tissue diseasesD00007407911
UrolithiasisD052878N20-N2311
Carotid artery injuriesD020212S15.011
Show 44 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameHEPARIN
INNheparin sodium
Description
Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. Since heparins depend on the activity of antithrombin, they are considered anticoagulants. Specifically it is also used in the treatment of heart attacks and unstable angina. It is given intravenously or by injection under the skin. Other uses for its anticoagulant properties include inside blood specimen test tubes and kidney dialysis machines.
Classification
Protein
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Identifiers
PDB
CAS-ID9005-49-6
RxCUI5224
ChEMBL IDCHEMBL1909300
ChEBI ID
PubChem CID22833565
DrugBankDB01109
UNII IDZZ45AB24CA (ChemIDplus, GSRS)
Target
Agency Approved
SERPINC1
SERPINC1
Organism
Homo sapiens
Gene name
SERPINC1
Gene synonyms
AT3
NCBI Gene ID
Protein name
antithrombin-III
Protein synonyms
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, Serpin C1, serpin peptidase inhibitor clade C member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Uniprot ID
Mouse ortholog
Serpinc1 (11905)
antithrombin-III (P32261)
Alternate
EGFR
EGFR
ERBB4
ERBB4
Organism
Homo sapiens
Gene name
EGFR
Gene synonyms
ERBB, ERBB1, HER1
NCBI Gene ID
Protein name
epidermal growth factor receptor
Protein synonyms
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EGFR vIII, epidermal growth factor receptor tyrosine kinase domain, erb-b2 receptor tyrosine kinase 1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Uniprot ID
Mouse ortholog
Egfr (13649)
epidermal growth factor receptor (Q01279)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 257,051 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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7,516 adverse events reported
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