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Halothane
Fluothane (halothane) is a small molecule pharmaceutical. Halothane was first approved as Fluothane on 1982-01-01. It is used to treat status asthmaticus in the USA. The pharmaceutical is active against potassium channel subfamily K member 9 and potassium channel subfamily K member 10. In addition, it is known to target potassium channel subfamily K member 12, potassium channel subfamily K member 2, potassium channel subfamily K member 3, potassium channel subfamily K member 5, potassium channel subfamily K member 13, potassium voltage-gated channel subfamily B member 1, and G protein-activated inward rectifier potassium channel 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Halothane
Tradename
Company
Number
Date
Products
FLUOTHANEWyethN-011338 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
status asthmaticus—D013224—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N01: Anesthetics
— N01A: Anesthetics, general
— N01AB: Halogenated hydrocarbons, general anesthetics
— N01AB01: Halothane
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
General anesthesiaD000768————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameHALOTHANE
INNhalothane
Description
Halothane is a haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position. It has a role as an inhalation anaesthetic. It is a haloalkane, an organofluorine compound, an organochlorine compound and an organobromine compound.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
FC(F)(F)C(Cl)Br
Identifiers
PDB1XZ1
CAS-ID151-67-7
RxCUI5095
ChEMBL IDCHEMBL931
ChEBI ID5615
PubChem CID3562
DrugBankDB01159
UNII IDUQT9G45D1P (ChemIDplus, GSRS)
Target
Agency Approved
KCNK9
KCNK9
KCNK10
KCNK10
Organism
Homo sapiens
Gene name
KCNK9
Gene synonyms
TASK3
NCBI Gene ID
51305
Protein name
potassium channel subfamily K member 9
Protein synonyms
Acid-sensitive potassium channel protein TASK-3, potassium 2-pore domain leak channel TASK3, potassium channel, two pore domain subfamily K, member 9, TWIK-related acid-sensitive K(+) channel 3, TWIK-related acid-sensitive K+ 3, Two pore K(+) channel KT3.2, Two pore potassium channel KT3.2
Uniprot ID
Q9NPC2
Mouse ortholog
Kcnk9 (223604)
potassium channel subfamily K member 9 (Q3LS21)
Alternate
KCNK12
KCNK12
KCNK2
KCNK2
KCNK3
KCNK3
KCNK5
KCNK5
KCNK13
KCNK13
KCNB1
KCNB1
KCNJ6
KCNJ6
Organism
Homo sapiens
Gene name
KCNK12
Gene synonyms
NCBI Gene ID
56660
Protein name
potassium channel subfamily K member 12
Protein synonyms
potassium channel, subfamily K, member 12, potassium channel, two pore domain subfamily K, member 12, Tandem pore domain halothane-inhibited potassium channel 2, tandem pore domain potassium channel THIK-2, THIK-2
Uniprot ID
Q9HB15
Mouse ortholog
Kcnk12 (210741)
potassium channel subfamily K member 12 (Q76M80)
Variants
Clinical Variant
Identifier
Target mutation
Effect
Evaluation
Status
VCV000575733CACNA1S, 520C>T, Arg174Trpdrug response2021-03-241A
VCV000017626CACNA1S, 3257G>A, Arg1086Hisdrug response2021-03-241A
VCV000012984RYR1, 14545G>A, Val4849Iledrug response2021-03-241A
VCV000012972RYR1, 7373G>A, Arg2458Hisdrug response2021-03-241A
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 23,950 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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208 adverse events reported
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