Skip to content
Haloperidol
Haldol (haloperidol) is a small molecule pharmaceutical. Haloperidol was first approved as Haldol on 1982-01-01. It is used to treat child behavior disorders, psychotic disorders, schizophrenia, schizophrenia spectrum and other psychotic disorders, and substance withdrawal syndrome amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor, D(4) dopamine receptor, D(2) dopamine receptor, and 5-hydroxytryptamine receptor 2A. In addition, it is known to target 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 1A, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 1D, potassium voltage-gated channel subfamily H member 1, histamine H1 receptor, D(1A) dopamine receptor, and G protein-activated inward rectifier potassium channel 2.
Download report
Favorite
Searched
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Haldol (generic drugs available since 1986-06-10, discontinued: Haldol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Haloperidol
Tradename
Company
Number
Date
Products
HALDOLJohnson & JohnsonN-015921 DISCN1982-01-01
6 products, RLD
HALDOL SOLUTABJohnson & JohnsonN-017079 DISCN1982-01-01
1 products
Hide discontinued
Haloperidol decanoate
Tradename
Company
Number
Date
Products
HALDOLJohnson & JohnsonN-018701 RX1986-01-14
2 products, RLD, RS
Haloperidol lactate
Tradename
Company
Number
Date
Products
HALDOLJohnson & JohnsonN-015923 DISCN1982-01-01
1 products, RLD
HALDOLJohnson & JohnsonN-015922 DISCN1982-01-01
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
haldol decanoateNew Drug Application2020-11-24
haloperidolANDA2023-05-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
child behavior disordersD002653
psychotic disordersD011618F20.81
schizophreniaEFO_0000692D012559F20
schizophrenia spectrum and other psychotic disordersD019967
substance withdrawal syndromeEFO_0005800D013375
tourette syndromeEFO_0004895D005879F95.2
vomitingHP_0002013D014839R11.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N05: Psycholeptics
N05A: Antipsychotics
N05AD: Butyrophenone derivatives, antipsychotics
N05AD01: Haloperidol
HCPCS
Code
Description
J1630
Injection, haloperidol, up to 5 mg
J1631
Injection, haloperidol decanoate, per 50 mg
Clinical
Clinical Trials
129 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F201915833
DeliriumD003693R41.07127427
Psychotic disordersD011618F20.811147114
Psychomotor agitationD0115951225
Bipolar disorderD001714EFO_0000289F30.92114
NauseaD009325HP_0002018R11.01124
Postoperative nausea and vomitingD020250EFO_0004888213
Migraine disordersD008881EFO_0003821G4333
Cognitive dysfunctionD060825G31.841113
DepressionD003863F33.9112
Show 15 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C803416
ConfusionD003221F44.8922
Critical illnessD016638112
DementiaD003704F0311
Psychophysiologic disordersD011602F45.911
Anxiety disordersD001008EFO_0006788F41.111
Mood disordersD019964EFO_0004247F30-F39111
Medication adherenceD055118EFO_000634411
Hip fracturesD006620EFO_0003964S72.0011
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Movement disordersD009069EFO_0004280G25112
Intellectual disabilityD008607F7311
Artificial respirationD01212111
Critical careD00342211
Ventilator weaningD01530011
GamblingD005715F63.011
Drug-induced akathisiaD017109EFO_1000903G25.7111
Cognition disordersD00307211
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients213
Therapeutic equivalencyD01381022
PlacebosD01091911
Huntington diseaseD006816G1011
Tobacco use disorderD014029F1711
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DyslipidemiasD050171HP_000311922
Insulin resistanceD007333EFO_000261422
StrokeD020521EFO_0000712I63.911
Female genital diseasesD005831EFO_0009549N8511
RecurrenceD01200811
ObesityD009765EFO_0001073E66.911
Metabolic syndromeD024821EFO_0000195E88.8111
Lactic acidosisD000140EFO_1000036E87.2011
Patient complianceD01034911
ChoreaD002819EFO_0004152G25.511
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameHALOPERIDOL
INNhaloperidol
Description
Haloperidol is a compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. It has a role as a serotonergic antagonist, a first generation antipsychotic, a dopaminergic antagonist, an antidyskinesia agent and an antiemetic. It is a hydroxypiperidine, an organofluorine compound, an aromatic ketone, a tertiary alcohol and a member of monochlorobenzenes.
Classification
Small molecule
Drug classantipsychotics (haloperidol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
Identifiers
PDB6LUQ
CAS-ID52-86-8
RxCUI5093
ChEMBL IDCHEMBL54
ChEBI ID5613
PubChem CID3559
DrugBankDB00502
UNII IDJ6292F8L3D (ChemIDplus, GSRS)
Target
Agency Approved
DRD3
DRD3
DRD4
DRD4
DRD2
DRD2
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
DRD3
Gene synonyms
NCBI Gene ID
Protein name
D(3) dopamine receptor
Protein synonyms
Dopamine D3 receptor, essential tremor 1
Uniprot ID
Mouse ortholog
Drd3 (13490)
D(3) dopamine receptor (P30728)
Alternate
HTR7
HTR7
HTR1A
HTR1A
DRD5
DRD5
HTR2B
HTR2B
HTR1D
HTR1D
KCNH1
KCNH1
HRH1
HRH1
DRD1
DRD1
KCNJ6
KCNJ6
Organism
Homo sapiens
Gene name
HTR7
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 7
Protein synonyms
5-HT-7, 5-HT-X, 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled), Serotonin receptor 7
Uniprot ID
Mouse ortholog
Htr7 (15566)
5-hydroxytryptamine receptor 7 (Q14A50)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 28,350 documents
View more details
Safety
Black-box Warning
Black-box warning for: Haldol decanoate, Haloperidol
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details