Gyki-52466
Gyki-52466 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glutamate receptor 2, glutamate receptor 3, glutamate receptor 4, and glutamate receptor 1.
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Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 2 | 1 | — | — | — | 3 | ||
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 3 | — | — | — | 3 |
| Dyskinesias | D020820 | G24 | 1 | 2 | — | — | — | 2 | |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | 2 | |
| Movement disorders | D009069 | EFO_0004280 | G25 | 1 | 1 | — | — | — | 1 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 1 | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | 1 | — | — | — | 1 | ||
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | — | — | — | 1 | |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 1 | — | — | — | 1 | |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GYKI-52466 |
| INN | talampanel |
| Description | GYKI 52466 is a benzodiazepine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1=NN=C(c2ccc(N)cc2)c2cc3c(cc2C1)OCO3 |
Identifiers
| PDB | — |
| CAS-ID | 102771-26-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL275006 |
| ChEBI ID | 79560 |
| PubChem CID | 3538 |
| DrugBank | — |
| UNII ID | CVS43XG1L5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GRIA2
GRIA2
GRIA3
GRIA3
GRIA4
GRIA4
GRIA1
GRIA1
Organism
Homo sapiens
Gene name
GRIA2
Gene synonyms
GLUR2
NCBI Gene ID
Protein name
glutamate receptor 2
Protein synonyms
AMPA receptor subunit GluA2, AMPA-selective glutamate receptor 2, GluA2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, glutamate receptor, ionotropic, AMPA 2
Uniprot ID
Mouse ortholog
Gria2 (14800)
glutamate receptor 2 (P23819)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 362 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10,100 adverse events reported
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