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Grepafloxacin
Raxar (grepafloxacin) is a small molecule pharmaceutical. Grepafloxacin was first approved as Raxar on 1997-11-06.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Grepafloxacin hydrochloride
Tradename
Company
Number
Date
Products
RAXAROtsukaN-020695 DISCN1997-11-06
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01M: Quinolone antibacterials
J01MA: Fluoroquinolone antibacterials, systemic
J01MA11: Grepafloxacin
HCPCS
No data
Clinical
Clinical Trials
30 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dental pulp necrosisD003790K04.1314
Periapical abscessD010482EFO_100120211
Urinary tract infectionsD014552EFO_0003103N39.011
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HordeolumD006726EFO_0007315H00.0111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart failureD006333EFO_0003144I50112
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Asymptomatic diseasesD05807011
RegenerationD01203811
Covid-19D000086382U07.111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gestational diabetesD016640HP_0009800O24.411
Breast neoplasmsD001943EFO_0003869C5011
Pituitary neoplasmsD01091111
Uterine ruptureD01459711
Premature birthD047928EFO_0003917O6011
Female infertilityD007247EFO_0008560N9711
Zenker diverticulumD016672EFO_100186711
Hypertrophic cardiomyopathyD002312EFO_0000538I42.111
BurnsD002056T30.011
Aortic valve stenosisD001024EFO_0000266Q25.111
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGREPAFLOXACIN
INNgrepafloxacin
Description
Grepafloxacin (trade name Raxar, Glaxo Wellcome) was an oral broad-spectrum fluoroquinolone antibacterial agent used to treat bacterial infections. Grepafloxacin was withdrawn worldwide from markets in 1999, due to its side effect of lengthening the QT interval on the electrocardiogram, leading to cardiac events and sudden death.
Classification
Small molecule
Drug classantibacterials (quinolone derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1c(F)c(N2CCNC(C)C2)cc2c1c(=O)c(C(=O)O)cn2C1CC1
Identifiers
PDB
CAS-ID119914-60-2
RxCUI83719
ChEMBL IDCHEMBL583
ChEBI ID5543
PubChem CID72474
DrugBankDB00365
UNII IDL1M1U2HC31 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 657 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,297 adverse events reported
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