Gramicidin
Neo-polycin (gramicidin) is a small molecule pharmaceutical. Gramicidin was first approved as Neo-polycin on 1982-01-01. It is used to treat bacterial eye infections and gram-positive bacterial infections in the USA.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| neo-polycin | ANDA | 2012-09-26 |
| neomycin and polymyxin b sulfates and gramicidin | ANDA | 2023-02-04 |
| neosporin plus pain relief | OTC monograph final | 2023-02-10 |
Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
238 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | C61 | 16 | 47 | 38 | 7 | 5 | 105 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 42 | 37 | 2 | 4 | 87 |
| Endometriosis | D004715 | EFO_0001065 | N80 | — | — | 1 | 4 | 2 | 7 |
| Leiomyoma | D007889 | HP_0000131 | D25 | — | — | 1 | 2 | — | 3 |
| Infertility | D007246 | EFO_0000545 | — | — | 2 | 1 | — | 3 | |
| X-linked bulbo-spinal atrophy | D055534 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adenocarcinoma | D000230 | 3 | 13 | 5 | — | — | 17 | ||
| Male breast neoplasms | D018567 | 2 | — | 3 | — | — | 5 | ||
| Castration-resistant prostatic neoplasms | D064129 | — | 1 | 2 | — | — | 2 | ||
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | 1 | — | 1 | 2 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | — | — | 1 | — | — | 1 |
| Drug therapy | D004358 | — | 1 | 1 | — | — | 1 | ||
| Breast diseases | D001941 | N60-N65 | — | 1 | 1 | — | — | 1 | |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | 1 | — | — | 1 |
| Hot flashes | D019584 | — | — | 1 | — | — | 1 | ||
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Triple negative breast neoplasms | D064726 | 2 | 7 | — | — | — | 8 | ||
| Neoplasms | D009369 | C80 | — | 3 | — | — | — | 3 | |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.81 | 1 | 1 | — | — | 1 | 3 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | — | 2 | — | — | — | 2 |
| Invasive hydatidiform mole | D002820 | D39.2 | — | 1 | — | — | — | 1 | |
| Hodgkin disease | D006689 | C81 | — | 1 | — | — | — | 1 | |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | — | 1 |
| Fallopian tube neoplasms | D005185 | — | 1 | — | — | — | 1 | ||
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Therapeutic equivalency | D013810 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | — | — | 1 | 1 |
| Nerve degeneration | D009410 | HP_0002180 | — | — | — | — | 1 | 1 | |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 1 | 1 |
| Psychotic disorders | D011618 | F20.81 | — | — | — | — | 1 | 1 | |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | — | 1 | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | — | 1 | 1 |
| Healthy volunteers/patients | — | — | — | — | — | 1 | 1 | ||
| Bone density | D015519 | EFO_0003923 | M85 | — | — | — | — | 1 | 1 |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | — | — | — | — | 1 | 1 |
| Ultrasonography | D014463 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GRAMICIDIN |
| INN | gramicidin s |
| Description | Gramicidin, also called gramicidin D, is a mix of ionophoric antibiotics, gramicidin A, B and C, which make up about 80%, 5%, and 15% of the mix, respectively. Each has 2 isoforms, so the mix has 6 different types of gramicidin molecules. They can be extracted from Brevibacillus brevis soil bacteria. Gramicidins are linear peptides with 15 amino acids. This is in contrast to unrelated gramicidin S, which is a cyclic peptide.
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| Classification | Small molecule |
| Drug class | natural antibiotics (undefined group) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C[C@@H](NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCO)C(C)C)C(C)C)C(C)C |
Identifiers
| PDB | — |
| CAS-ID | 1405-97-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201469 |
| ChEBI ID | — |
| PubChem CID | 45267103 |
| DrugBank | DB00027 |
| UNII ID | WHM29QA23F (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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6,477 adverse events reported
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