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Gonadorelin
Factrel, Lutrepulse (gonadorelin) is a protein pharmaceutical. Gonadorelin was first approved as Factrel on 1982-09-30. It is used to treat amenorrhea, delayed puberty, ovarian cysts, and precocious puberty in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Gonadorelin acetate
Tradename
Company
Number
Date
Products
LUTREPULSE KITFerring PharmaceuticalsN-019687 DISCN1989-10-10
2 products
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Gonadorelin hydrochloride
Tradename
Company
Number
Date
Products
FACTRELHikma PharmaceuticalsN-018123 DISCN1982-09-30
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
amenorrheaD000568N91.2
delayed pubertyHP_0000823D011628E30.0
ovarian cystsHP_0000138D010048N83.1
precocious pubertyD011629E22.8
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
H01: Pituitary and hypothalamic hormones and analogues
H01C: Hypothalamic hormones
H01CA: Gonadotropin-releasing hormones
H01CA01: Gonadorelin
V: Various drug classes in atc
V04: Diagnostic agents
V04C: Other diagnostic agents in atc
V04CM: Fertility disturbances test diagnostic agents
V04CM01: Gonadorelin
HCPCS
Code
Description
J1620
Injection, gonadorelin hydrochloride, per 100 mcg
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD00228911
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5011
LeukemiaD007938C9511
Myelodysplastic syndromesD009190D4611
Ovarian neoplasmsD010051EFO_0003893C5611
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGONADORELIN
INNgonadorelin
Description
Gonadorelin is a ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It has a role as a gonadotropin releasing hormone agonist. It is an oligopeptide and a peptide hormone.
Classification
Protein
Drug classprehormones or hormone-release stimulating peptides
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O
Identifiers
PDB
CAS-ID33515-09-2
RxCUI6384
ChEMBL IDCHEMBL1007
ChEBI ID5520
PubChem CID638793
DrugBankDB00644
UNII ID9O7312W37G (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 552 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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151 adverse events reported
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