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Oxiglutatione
Navstel (oxiglutatione) is a small molecule pharmaceutical. Oxiglutatione was first approved as Navstel on 2008-07-24. The pharmaceutical is active against glutathione reductase, mitochondrial. In addition, it is known to target glutathione S-transferase Mu 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcium chloride
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Dextrose
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Magnesium chloride
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Oxiglutatione
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Potassium chloride
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Sodium bicarbonate
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Sodium chloride
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Sodium phosphate
Tradename
Company
Number
Date
Products
NAVSTELAlcon ResearchN-022193 DISCN2008-07-24
1 products
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOXIGLUTATIONE
INNoxiglutatione
Description
Glutathione disulfide (GSSG) is a disulfide derived from two glutathione molecules.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O
Identifiers
PDB1YKC
CAS-ID27025-41-8
RxCUI25953
ChEMBL IDCHEMBL1372
ChEBI ID17858
PubChem CID11215652
DrugBankDB03310
UNII IDULW86O013H (ChemIDplus, GSRS)
Target
Agency Approved
GSR
GSR
Organism
Homo sapiens
Gene name
GSR
Gene synonyms
GLUR, GRD1
NCBI Gene ID
2936
Protein name
glutathione reductase, mitochondrial
Protein synonyms
epididymis luminal protein 75, epididymis secretory sperm binding protein Li 122m, glutathione S-reductase, GRase
Uniprot ID
Q9NP63
Mouse ortholog
Gsr (14782)
glutathione reductase, mitochondrial (Q8C9Z6)
Alternate
GSTM2
GSTM2
Organism
Homo sapiens
Gene name
GSTM2
Gene synonyms
GST4
NCBI Gene ID
2946
Protein name
glutathione S-transferase Mu 2
Protein synonyms
epididymis secretory sperm binding protein, glutathione S-alkyltransferase M2, glutathione S-aralkyltransferase M2, glutathione S-aryltransferase M2, glutathione S-transferase 4, glutathione S-transferase M1, glutathione S-transferase M2 (muscle), glutathione S-transferase mu 2 (muscle), GST class-mu 2, GST, muscle, GSTM2-2, S-(hydroxyalkyl)glutathione lyase M2
Uniprot ID
Q8WWE1
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 15 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5 adverse events reported
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