Gentian violet
Genapax, Gvs (gentian violet) is a small molecule pharmaceutical. Gentian violet was first approved as Genapax on 1982-01-01. It is used to treat chronic mucocutaneous candidiasis, cutaneous candidiasis, staphylococcal skin infections, and vulvovaginal candidiasis in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
| skin and connective tissue diseases | D017437 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| el valle gentian violet | OTC monograph not final | 2023-05-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| chronic mucocutaneous candidiasis | Orphanet_1334 | D002178 | B37.2 |
| cutaneous candidiasis | — | D002179 | — |
| staphylococcal skin infections | EFO_1001849 | D013207 | L00 |
| vulvovaginal candidiasis | EFO_0007543 | D002181 | B37.3 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
144 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 3 | 4 | 3 | 10 | |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | 3 | 1 | 4 | 1 | 8 |
| Sepsis | D018805 | A41.9 | — | — | 3 | 1 | 4 | 8 | |
| Diabetic foot | D017719 | EFO_1001459 | 1 | 4 | 2 | 1 | — | 7 | |
| Appendicitis | D001064 | EFO_0007149 | K37 | — | — | — | 2 | 2 | 4 |
| Acoustic neuroma | D009464 | HP_0009588 | — | — | — | 2 | 2 | 4 | |
| Wound infection | D014946 | — | — | 1 | 2 | — | 3 | ||
| Endocarditis | D004696 | EFO_0000465 | I33 | — | — | 1 | 1 | 1 | 3 |
| Neonatal sepsis | D000071074 | HP_0040187 | — | 1 | 2 | 1 | — | 3 | |
| Gonorrhea | D006069 | DOID_7551 | A54 | — | — | 1 | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Surgical wound infection | D013530 | — | 1 | 4 | — | 1 | 5 | ||
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 1 | 2 | — | 2 | 4 |
| Chorioamnionitis | D002821 | O41.12 | — | 2 | 2 | — | 2 | 4 | |
| Kidney calculi | D007669 | EFO_0004253 | N20.0 | — | — | 1 | — | 1 | 2 |
| Plague | D010930 | EFO_0007481 | A20 | — | 1 | 2 | — | — | 2 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | 2 | 1 | — | — | 2 | |
| Neurogenic urinary bladder | D001750 | HP_0000011 | N31 | — | 2 | 1 | — | — | 2 |
| Cat-scratch disease | D002372 | EFO_0007195 | A28.1 | — | — | 1 | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 1 | — | — | 1 |
| Microbial drug resistance | D004352 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | 1 | 1 | — | — | 1 | 3 |
| Respiratory tract infections | D012141 | J06.9 | 1 | 1 | — | — | 1 | 3 | |
| Cutaneous leishmaniasis | D016773 | B55.1 | — | 3 | — | — | — | 3 | |
| Epidermolysis bullosa dystrophica | D016108 | Q81.2 | 3 | 3 | — | — | — | 3 | |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 2 | — | — | — | 2 |
| Junctional epidermolysis bullosa | D016109 | Q81.1 | 2 | 2 | — | — | — | 2 | |
| Abdominal abscess | D018784 | EFO_1001753 | — | 1 | — | — | — | 1 | |
| Nasopharyngeal neoplasms | D009303 | — | 1 | — | — | — | 1 | ||
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 1 | — | — | — | 1 |
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Duchenne muscular dystrophy | D020388 | 2 | — | — | — | — | 2 | ||
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | — | 1 |
| Inflammation | D007249 | 1 | — | — | — | — | 1 | ||
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 1 | — | — | — | — | 1 |
| Mammaplasty | D016462 | 1 | — | — | — | — | 1 | ||
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Endometritis | D004716 | EFO_1001312 | — | — | — | — | 1 | 1 | |
| Cerebral hemorrhage | D002543 | — | — | — | — | 1 | 1 | ||
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | — | 1 | 1 |
| Drug monitoring | D016903 | — | — | — | — | 1 | 1 | ||
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | — | — | 1 | 1 |
| Critical illness | D016638 | — | — | — | — | 1 | 1 | ||
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 1 | 1 |
| Gastrointestinal diseases | D005767 | — | — | — | — | 1 | 1 | ||
| Colic | D003085 | HP_0011848 | R10.83 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GENTIAN VIOLET |
| INN | methylrosanilinium chloride |
| Description | Methyl violet is a family of organic compounds that are mainly used as dyes. Depending on the number of attached methyl groups, the color of the dye can be altered. Its main use is as a purple dye for textiles and to give deep violet colors in paint and ink, it is also used as a hydration indicator for silica gel. Methyl violet 10B is also known as crystal violet (and many other names) and has medical uses.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1.[Cl-] |
Identifiers
| PDB | — |
| CAS-ID | 548-62-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL64894 |
| ChEBI ID | 41688 |
| PubChem CID | 196986 |
| DrugBank | DB00406 |
| UNII ID | J4Z741D6O5 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6,687 adverse events reported
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