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Gefapixant
Gefapixant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target P2X purinoceptor 3.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
R05: Cough and cold preparations
R05D: Cough suppressants, excl. combinations with expectorants
R05DB: Other cough suppressants in atc
R05DB29: Gefapixant
HCPCS
No data
Clinical
Clinical Trials
26 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Idiopathic pulmonary fibrosisD054990J84.11222
Knee osteoarthritisD020370EFO_0004616M1711
AsthmaD001249EFO_0000270J4511
CoughD003371HP_0012735R0511
Interstitial cystitisD018856EFO_1000869N30.111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients33
Obstructive sleep apneaD020181EFO_0003918G47.3311
Renal insufficiencyD051437HP_0000083N1911
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameGEFAPIXANT
INNgefapixant
Description
Gefapixant (MK-7264) is a drug which acts as an antagonist of the P2RX3 receptor, and may be useful in the treatment of chronic cough. It was named in honour of Geoff Burnstock.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O
Identifiers
PDB
CAS-ID1015787-98-0
RxCUI
ChEMBL IDCHEMBL3716057
ChEBI ID
PubChem CID24764487
DrugBankDB15097
UNII ID6K6L7E3F1L (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
P2RX3
P2RX3
Organism
Homo sapiens
Gene name
P2RX3
Gene synonyms
NCBI Gene ID
Protein name
P2X purinoceptor 3
Protein synonyms
ATP receptor, P2X receptor, subunit 3, Purinergic receptor, purinergic receptor P2X, ligand gated ion channel, 3, purinergic receptor P2X3, purinoceptor P2X3
Uniprot ID
Mouse ortholog
P2rx3 (228139)
P2X purinoceptor 3 (Q8R1U4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 208 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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