Ablavar, Ablavar (previously vasovist)(gadofosveset)
Ablavar, Vasovist (gadofosveset) is a small molecule pharmaceutical. Gadofosveset was first approved as Ablavar (previously vasovist) on 2005-10-03. It has been approved in Europe to treat magnetic resonance angiography.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| diagnosis | D003933 |
Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Gadofosveset trisodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ABLAVAR | Lantheus Medical Imaging | N-021711 DISCN | 2008-12-22 | 2 products |
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FDA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| A9583 | Injection, gadofosveset trisodium, 1 ml |
Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | 1 | 1 | — | 2 | ||
| Orthopedic procedures | D019637 | — | — | — | 1 | — | 1 | ||
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery bypass | D001026 | EFO_0003776 | — | 1 | — | — | — | 1 | |
| Artificial respiration | D012121 | — | 1 | — | — | — | 1 | ||
| Intubation | D007440 | — | 1 | — | — | — | 1 | ||
| Critical illness | D016638 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Interstitial cystitis | D018856 | EFO_1000869 | N30.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GADOFOSVESET |
| INN | gadofosveset |
| Description | Gadofosveset (trade names Vasovist, Ablavar) is a gadolinium-based MRI contrast agent. It was used as the trisodium salt monohydrate form. It acts as a blood pool agent by binding to human serum albumin. The manufacturer (Lantheus Medical) discontinued production in 2017 due to poor sales.
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| Classification | Small molecule |
| Drug class | phosphoro-derivatives; gadolinium derivatives (principally for diagnostic use) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C([O-])CN(CCN(CC(=O)[O-])C[C@H](COP(=O)([O-])OC1CCC(c2ccccc2)(c2ccccc2)CC1)N(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3].[Na+].[Na+].[Na+] |
Identifiers
| PDB | — |
| CAS-ID | 193901-90-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1908843 |
| ChEBI ID | — |
| PubChem CID | 11672461 |
| DrugBank | DB06705 |
| UNII ID | E65RW73PHS (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
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Additional graphs summarizing 759 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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9 adverse events reported
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