Forodesine
Forodesine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against purine nucleoside phosphorylase.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
14 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | C85.9 | 3 | 3 | — | — | — | 4 | |
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 1 | 2 | — | — | — | 3 | |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | 2 | 2 | — | — | — | 2 | ||
| Non-hodgkin lymphoma | D008228 | C85.9 | 1 | 1 | — | — | — | 1 | |
| Precursor b-cell lymphoblastic leukemia-lymphoma | D015452 | 1 | 1 | — | — | — | 1 | ||
| T-cell lymphoma cutaneous | D016410 | C84.A | — | 1 | — | — | — | 1 | |
| Leukemia | D007938 | C95 | — | 1 | — | — | — | 1 | |
| T-cell leukemia | D015458 | — | 1 | — | — | — | 1 | ||
| Lymphoid leukemia | D007945 | C91 | 1 | 1 | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | FORODESINE |
| INN | forodesine |
| Description | Forodesine (INN; also known as Immucillin H; trade names Mundesine and Fodosine) is a transition-state analog inhibitor of purine nucleoside phosphorylase studied for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and for treatment of B-cell acute lymphocytic leukemia (B-ALL).
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=c1[nH]cnc2c([C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)c[nH]c12 |
Identifiers
| PDB | 1NW4 |
| CAS-ID | 209799-67-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL218291 |
| ChEBI ID | 43362 |
| PubChem CID | 444499 |
| DrugBank | DB06185 |
| UNII ID | 426X066ELK (ChemIDplus, GSRS) |
Target
Agency Approved
PNP
PNP
Organism
Homo sapiens
Gene name
PNP
Gene synonyms
NP
NCBI Gene ID
Protein name
purine nucleoside phosphorylase
Protein synonyms
epididymis secretory sperm binding protein Li 156an, HEL-S-156an, Inosine phosphorylase, Inosine-guanosine phosphorylase, purine-nucleoside:orthophosphate ribosyltransferase
Uniprot ID
Mouse ortholog
Pnp (18950)
purine nucleoside phosphorylase (P23492)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 244 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more