Skip to content
Folic acid
Berocca Pn, Folicet, Folvite, Folvron, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vitaped (folic acid) is a small molecule pharmaceutical. Folic acid was first approved as Folvron on 1982-01-01. It is used to treat folic acid deficiency and megaloblastic anemia in the USA. It is known to target proton-coupled folate transporter and reduced folate transporter.
Download report
Favorite
Searched
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
hemic and lymphatic diseasesD006425
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Combinations
Infuvite (discontinued: Berocca pn, Folvron, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE ADULTSandozN-021163 RX2000-05-18
2 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)SandozN-021265 RX2004-01-29
1 products, RLD, RS
INFUVITE PEDIATRICSandozN-021265 RX2001-02-21
1 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 LYOPHILIZEDTeligentN-018933 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 ADULTHospiraN-008809 DISCN2004-04-22
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.C. 9+3APP PharmaceuticalsN-018440 DISCN1985-08-08
1 products
M.V.I.-12 ADULTHospiraN-008809 DISCN1985-08-08
2 products
MVC PLUSAllerganN-018439 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Tradename
Company
Number
Date
Products
M.V.I. ADULTHospiraN-021625 DISCN2004-01-30
1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)HospiraN-021643 DISCN2004-02-18
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
BEROCCA PNRocheN-006071 DISCN1985-10-10
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
Hide discontinued
Ferrous sulfate
+
Folic acid
Tradename
Company
Number
Date
Products
FOLVRONLederle LaboratoriesN-006012 DISCN1982-01-01
1 products
Hide discontinued
Folic acid
Tradename
Company
Number
Date
Products
FOLIC ACIDEli LillyN-006135 DISCN1982-01-01
1 products
FOLVITEWYETH PHARMS INCN-005897 DISCN1982-01-01
2 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
adult infuvite multiple vitaminsNew Drug Application2016-10-28
folic acidANDA2023-06-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
folic acid deficiencyEFO_0001070D005494E53.8
megaloblastic anemia—D000749D53.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B03: Antianemic preparations
— B03A: Iron antianemic preparations
— B03AD: Iron in combination with folic acid
— B03AE: Iron in other combinations
— B03AE01: Iron, vitamin b12 and folic acid
— B03AE02: Iron, multivitamins and folic acid
— B03B: Vitamin b12 and folic acid
— B03BB: Folic acid and derivatives as antianemics
— B03BB01: Folic acid
— B03BB51: Folic acid, combinations
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01B: Antimetabolites
— L01BA: Folic acid analogs, antimetabolites
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CX: Other diagnostic agents in atc
— V04CX02: Folic acid
HCPCS
No data
Clinical
Clinical Trials
525 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9417116—36
AnemiaD000740EFO_0004272D64.913421524
Polycystic ovary syndromeD011085EFO_0000660E28.213151018
NeoplasmsD009369C807742—16
Cardiovascular diseasesD002318EFO_0000319I98—21328
PregnancyD011247EFO_0002950Z33.1——1258
SchizophreniaD012559EFO_0000692F20——1438
Gestational diabetesD016640HP_0009800O24.4—11157
HyperhomocysteinemiaD020138———336
StrokeD020521EFO_0000712I63.9——2226
Show 30 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD01517973518—459
Non-small-cell lung carcinomaD002289185—214
Stomach neoplasmsD013274EFO_0003897C163101——13
Pancreatic neoplasmsD010190EFO_0003860C25472——11
Iron-deficiency anemiaD018798HP_0001891D50—22—811
Rectal neoplasmsD012004233——7
Neoplasm metastasisD009362EFO_0009708251——7
Ovarian neoplasmsD010051EFO_0003893C56521—17
Folic acid deficiencyD005494EFO_0001070E53.8—11—56
Lung neoplasmsD008175C34.90—41—15
Show 67 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AdenocarcinomaD00023025———6
Fallopian tube neoplasmsD00518551———5
InflammationD007249—1——34
OverweightD050177E66.3—1——23
Autistic disorderD001321EFO_0003758F84.0—2——13
Uterine cervical neoplasmsD00258312——13
Head and neck neoplasmsD006258—2———2
Triple negative breast neoplasmsD06472611———2
Small cell lung carcinomaD05575221———2
Peritoneal neoplasmsD01053421———2
Show 38 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—5———914
PharmacokineticsD0105995————5
Cognitive dysfunctionD060825G31.841———34
T-cell lymphoma cutaneousD016410C84.A2————2
Drug interactionsD0043472————2
Therapeutic equivalencyD0138102————2
Gastrointestinal stromal tumorsD046152EFO_0000505C49.A1————1
Squamous cell carcinoma of head and neckD0000771951————1
Esophageal squamous cell carcinomaD0000772771————1
GlioblastomaD005909EFO_00005151————1
Show 18 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G20————22
Gyrate atrophyD015799————22
Transient ischemic attackD002546EFO_0003764G45.9————22
MortalityD009026EFO_0004352————22
Birth weightD001724EFO_0004344————22
Spinal dysraphismD016135EFO_1001210Q05————22
ParturitionD036801————11
Low back painD017116HP_0003419M54.5————11
Live birthD050498————11
PsoriasisD011565EFO_0000676L40————11
Show 72 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameFOLIC ACID
INNfolic acid
Description
Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and storage. Folate is required for the body to make DNA and RNA and metabolise amino acids necessary for cell division. As humans cannot make folate, it is required in the diet, making it an essential nutrient. It occurs naturally in many foods. The recommended adult daily intake of folate in the U.S. is 400 micrograms from foods or dietary supplements.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Nc1nc(=O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2[nH]1
Identifiers
PDB—
CAS-ID59-30-3
RxCUI4511
ChEMBL IDCHEMBL1622
ChEBI ID27470
PubChem CID6037
DrugBankDB00158
UNII ID935E97BOY8 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SLC46A1
SLC46A1
SLC19A1
SLC19A1
Organism
Homo sapiens
Gene name
SLC46A1
Gene synonyms
G21, HCP1, PCFT
NCBI Gene ID
113235
Protein name
proton-coupled folate transporter
Protein synonyms
Heme carrier protein 1, PCFT/HCP1, solute carrier family 46 (folate transporter), member 1, Solute carrier family 46 member 1
Uniprot ID
Q96NT5
Mouse ortholog
Slc46a1 (52466)
proton-coupled folate transporter (Q9D1P1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 74,147 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
3,191 adverse events reported
View more details