Flutamide
Eulexin (flutamide) is a small molecule pharmaceutical. Flutamide was first approved as Eulexin on 1989-01-27. It is used to treat hirsutism and prostatic neoplasms in the USA. The pharmaceutical is active against androgen receptor.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| urogenital diseases | D000091642 |
| skin and connective tissue diseases | D017437 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Flutamide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EULEXIN | Merck Sharp & Dohme | N-018554 DISCN | 1989-01-27 | 1 products, RLD |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hirsutism | HP_0001007 | D006628 | L68.0 |
| prostatic neoplasms | — | D011471 | C61 |
Agency Specific
FDA
EMA
No data
Patent Expiration
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HCPCS
Code | Description |
|---|---|
| S0175 | Flutamide, oral, 125 mg |
Clinical
Clinical Trials
57 clinical trials
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 7 | 1 | — | — | 1 | 8 | ||
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 1 | — | — | 1 | 2 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 2 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | 3 | — | — | — | — | 3 | ||
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 3 | — | — | — | — | 3 |
| Mitochondrial diseases | D028361 | EFO_0000591 | 1 | — | — | — | — | 1 | |
| Infections | D007239 | EFO_0000544 | 1 | — | — | — | — | 1 | |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | — | — | 1 |
| Anemia | D000740 | EFO_0004272 | D64.9 | 1 | — | — | — | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | — | 1 |
| Oral surgery | D013515 | 1 | — | — | — | — | 1 | ||
| Bone resorption | D001862 | 1 | — | — | — | — | 1 | ||
| Stress fractures | D015775 | M84.3 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | — | — | 4 | 4 | ||
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Headache | D006261 | HP_0002315 | R51 | — | — | — | — | 1 | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 1 | 1 |
| Tendinopathy | D052256 | EFO_1001434 | M77.9 | — | — | — | — | 1 | 1 |
| Synovitis | D013585 | EFO_0008997 | M67.5 | — | — | — | — | 1 | 1 |
| Spasm | D013035 | M62.83 | — | — | — | — | 1 | 1 | |
| Radiculopathy | D011843 | M54.1 | — | — | — | — | 1 | 1 | |
| Gout | D006073 | EFO_0004274 | M10 | — | — | — | — | 1 | 1 |
| Anaplasia | D000708 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FLUTAMIDE |
| INN | flutamide |
| Description | Flutamide is a monocarboxylic acid amide and a member of (trifluoromethyl)benzenes. It has a role as an androgen antagonist and an antineoplastic agent. |
| Classification | Small molecule |
| Drug class | non-steroid antiandrogens |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 13311-84-7 |
| RxCUI | 4508 |
| ChEMBL ID | CHEMBL806 |
| ChEBI ID | 5132 |
| PubChem CID | 3397 |
| DrugBank | DB00499 |
| UNII ID | 76W6J0943E (ChemIDplus, GSRS) |
Target
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Eulexin, Flutamide
Adverse Events
Top Adverse Reactions
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892 adverse events reported
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