Flurbiprofen
Ansaid, Ocufen (flurbiprofen) is a small molecule pharmaceutical. Flurbiprofen was first approved as Ocufen on 1986-12-31. It is used to treat inflammation, macular edema, miosis, osteoarthritis, and rheumatoid arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target acid-sensing ion channel 1.
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Commercial
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| flurbiprofen | ANDA | 2023-06-13 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| inflammation | MP_0001845 | D007249 | — |
| macular edema | — | D008269 | — |
| miosis | HP_0000616 | D015877 | H57.03 |
| osteoarthritis | EFO_0002506 | D010003 | M15-M19 |
| rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AE: Propionic acid derivatives, antiinflammatory and antirheumatic products
— M01AE09: Flurbiprofen
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA19: Flurbiprofen
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AX: Other throat preparations in atc
— R02AX01: Flurbiprofen
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01B: Antiinflammatory agents, ophthalmologic
— S01BC: Antiinflammatory agents, non-steroidal, ophthalmologic
— S01BC04: Flurbiprofen
HCPCS
No data
Clinical
Clinical Trials
26 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 1 | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 2 | — | — | — | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 1 | — | — | — | 1 |
| Hepatic encephalopathy | D006501 | K72.91 | 1 | 1 | — | — | — | 1 | |
| Narcolepsy | D009290 | EFO_0000614 | G47.4 | 1 | 1 | — | — | — | 1 |
| Idiopathic hypersomnia | D020177 | G47.11 | 1 | 1 | — | — | — | 1 | |
| Disorders of excessive somnolence | D006970 | G47.1 | 1 | 1 | — | — | — | 1 | |
| Healthy volunteers/patients | — | 1 | 1 | — | — | — | 1 | ||
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | 1 | — | — | — | 1 |
| Dental anxiety | D016854 | 1 | 1 | — | — | — | 1 | ||
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 2 | 2 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | 1 | 1 | |
| Colonoscopy | D003113 | — | — | — | — | 1 | 1 | ||
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | — | — | 1 | 1 | |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | 1 | 1 | |
| Ambulatory surgical procedures | D000556 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FLURBIPROFEN |
| INN | flurbiprofen |
| Description | Flurbiprofen is a monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is a fluorobiphenyl and a monocarboxylic acid. It is functionally related to a propionic acid. It derives from a hydride of a biphenyl. |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 5104-49-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL563 |
| ChEBI ID | 5130 |
| PubChem CID | 3394 |
| DrugBank | DB00712 |
| UNII ID | 5GRO578KLP (ChemIDplus, GSRS) |
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
ASIC1
ASIC1
Organism
Homo sapiens
Gene name
ASIC1
Gene synonyms
ACCN2, BNAC2
NCBI Gene ID
Protein name
acid-sensing ion channel 1
Protein synonyms
acid sensing (proton gated) ion channel 1, acid-sensing ion channel 1a protein, Amiloride-sensitive cation channel 2, neuronal, BNaC2, Brain sodium channel 2, Cation channel, amiloride-sensitive, neuronal, 2
Uniprot ID
Mouse ortholog
Asic1 (11419)
acid-sensing ion channel 1 (Q6NXK8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,348 documents
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Safety
Black-box Warning
Black-box warning for: Flurbiprofen
Adverse Events
Top Adverse Reactions
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360 adverse events reported
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