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Fluphenazine decanoate
Permitil, Prolixin (fluphenazine decanoate) is a small molecule pharmaceutical. Fluphenazine decanoate was first approved as Prolixin decanoate on 1982-01-01. It is used to treat psychotic disorders and schizophrenia in the USA. It is known to target 5-hydroxytryptamine receptor 6, D(1A) dopamine receptor, D(1B) dopamine receptor, D(2) dopamine receptor, histamine H1 receptor, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 2A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fluphenazine decanoate
Tradename
Company
Number
Date
Products
PROLIXIN DECANOATEBristol Myers SquibbN-016727 DISCN1982-01-01
1 products, RLD
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Fluphenazine enanthate
Tradename
Company
Number
Date
Products
PROLIXIN ENANTHATEBristol Myers SquibbN-016110 DISCN1982-01-01
1 products
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Fluphenazine hydrochloride
Tradename
Company
Number
Date
Products
PROLIXINBristol Myers SquibbN-011751 DISCN1982-01-01
5 products
PROLIXINBristol Myers SquibbN-012145 DISCN1982-01-01
1 products, RLD
PERMITILMerck Sharp & DohmeN-012034 DISCN1982-01-01
4 products
PERMITILMerck Sharp & DohmeN-012419 DISCN1982-01-01
1 products
PERMITILMerck Sharp & DohmeN-016008 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
fluphenazine decanoateANDA2023-04-04
fluphenazine hydrochlorideANDA2023-05-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
psychotic disorders—D011618F20.81
schizophreniaEFO_0000692D012559F20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AB: Phenothiazines with piperazine structure, antipsychotics
— N05AB02: Fluphenazine
HCPCS
Code
Description
J2680
Injection, fluphenazine decanoate, up to 25 mg
Clinical
Clinical Trials
19 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cervical intraepithelial neoplasiaD018290D06—2———2
Breast neoplasmsD001943EFO_0003869C50—1———1
Uterine cervical dysplasiaD002578EFO_1000910N8711———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peanut hypersensitivityD021183EFO_00074252————2
Allergic rhinitisD065631J30.91————1
Allergic conjunctivitisD003233EFO_0007141H10.441————1
PharmacokineticsD0105991————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.9————33
ParesisD010291HP_0001269————33
Mobility limitationD051346HP_0002355————33
HemorrhoidsD006484EFO_0009552K64————22
Postoperative painD010149G89.18————11
Spinal cord injuriesD013119EFO_1001919————11
Neurologic gait disordersD020233R26.1————11
CoughD003371HP_0012735R05————11
PharyngitisD010612R07.0————11
Rectal neoplasmsD012004————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFLUPHENAZINE DECANOATE
INNfluphenazine
Description
Fluphenazine is a member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and an anticoronaviral agent. It is an organofluorine compound, a member of phenothiazines and a N-alkylpiperazine. It derives from a hydride of a 10H-phenothiazine.
Classification
Small molecule
Drug classTypical antipsychotic
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCCCCCCC(=O)OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1
Identifiers
PDB—
CAS-ID69-23-8
RxCUI4496
ChEMBL IDCHEMBL1200854
ChEBI ID—
PubChem CID3372
DrugBankDB00623
UNII IDS79426A41Z (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR6
HTR6
DRD1
DRD1
DRD5
DRD5
DRD2
DRD2
HRH1
HRH1
HTR7
HTR7
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR6
Gene synonyms
NCBI Gene ID
3362
Protein name
5-hydroxytryptamine receptor 6
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled, Serotonin receptor 6
Uniprot ID
Q5TGZ1
Mouse ortholog
Htr6 (15565)
5-hydroxytryptamine receptor 6 (Q9R1C8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 3,889 documents
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Safety
Black-box Warning
Black-box warning for: Fluphenazine decanoate, Fluphenazine hydrochloride
Adverse Events
Top Adverse Reactions
Mock data
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30 adverse events reported
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