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Flumethasone pivalate
Locorten (flumethasone pivalate) is a small molecule pharmaceutical. Flumethasone pivalate was first approved as Locorten on 1982-01-01. It is used to treat atopic dermatitis, contact dermatitis, diaper rash, eczema, and otitis externa amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
otorhinolaryngologic diseasesD010038
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Flumethasone pivalate
Tradename
Company
Number
Date
Products
LOCORTENNovartisN-016379 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atopic dermatitisEFO_0000274D003876L20
contact dermatitisD003877L25
diaper rashD003963L22
eczemaHP_0000964D004485L30.9
otitis externaEFO_0009560D010032H60
otomycosisD059249
psoriasisEFO_0000676D011565L40
skin diseasesD012871L00-L99
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
D07: Corticosteroids, dermatological preparations
D07A: Corticosteroid dermatological preparations, plain
D07AB: Corticosteroids, moderately potent (group ii)
D07AB03: Flumetasone
D07B: Corticosteroids, combinations with antiseptics
D07BB: Corticosteroids, moderately potent, combinations with antiseptics
D07BB01: Flumetasone and antiseptics
D07C: Corticosteroids, combinations with antibiotics
D07CB: Corticosteroids, moderately potent, combinations with antibiotics
D07CB05: Flumetasone and antibiotics
D07X: Corticosteroids, other combinations
D07XB: Corticosteroids, moderately potent, other combinations
D07XB01: Flumetasone
S: Sensory organ drugs
S02: Otologicals
S02C: Corticosteroids and antiinfectives in combination, otologic
S02CA: Corticosteroids and antiinfectives in combination
S02CA02: Flumetasone and antiinfectives
HCPCS
No data
Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cryptococcal meningitisD016919EFO_0007228B45.142712
Hiv infectionsD015658EFO_0000764B202158
GlioblastomaD005909EFO_00005154215
AstrocytomaD001254EFO_00002713114
OligodendrogliomaD009837EFO_00006312113
HivD006678O98.7111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Brain neoplasmsD001932EFO_0003833C71313
Colorectal neoplasmsD015179222
NeoplasmsD009369C80222
Digestive system neoplasmsD004067111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GliomaD005910EFO_000052022
GliosarcomaD01831622
Gastrointestinal neoplasmsD005770C26.911
Urinary bladder neoplasmsD001749C6711
Liver neoplasmsD008113EFO_1001513C22.011
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFLUMETHASONE PIVALATE
INNflumetasone
Description
Flumethasone is a fluorinated steroid, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug. It derives from a hydride of a pregnane.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C(C)(C)C
Identifiers
PDB
CAS-ID2002-29-1
RxCUI4458
ChEMBL IDCHEMBL1200877
ChEBI ID31620
PubChem CID16490
DrugBankDB00663
UNII IDLR3CD8SX89 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 106 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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470 adverse events reported
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