Fludarabine phosphate
Fludara, Oforta (fludarabine phosphate) is a small molecule pharmaceutical. Fludarabine phosphate was first approved as Fludara on 1991-04-18. It is used to treat b-cell chronic lymphocytic leukemia and non-hodgkin lymphoma in the USA.
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Fludarabine phosphate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| FLUDARABINE PHOSPHATE | Sandoz | N-022137 RX | 2007-09-21 | 1 products, RLD, RS |
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Brand Name | Status | Last Update |
|---|---|---|
| fludarabine phosphate | ANDA | 2021-07-22 |
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Clinical
Clinical Trials
36 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 3 | 6 | 8 | 6 | 22 |
| Ventricular premature complexes | D018879 | I49.3 | — | 1 | — | 2 | 1 | 4 | |
| Ventricular tachycardia | D017180 | I47.2 | — | 1 | 1 | 2 | — | 4 | |
| Brugada syndrome | D053840 | Orphanet_130 | I49.8 | — | — | — | 1 | 1 | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Supraventricular tachycardia | D013617 | HP_0004755 | I47.1 | — | — | 1 | — | 2 | 3 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 1 | 2 | — | — | 3 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | 2 | — | — | 3 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | 1 | 1 | — | 1 | 3 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 2 | — | — | 2 |
| Recurrence | D012008 | — | 1 | 1 | — | — | 1 | ||
| Atrial flutter | D001282 | EFO_0003911 | — | — | 1 | — | — | 1 | |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | — | 1 |
| Coronary disease | D003327 | — | — | 1 | — | — | 1 | ||
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arrhythmogenic right ventricular dysplasia | D019571 | Orphanet_247 | I42.8 | — | 1 | — | — | 1 | 2 |
| Blood pressure | D001794 | EFO_0004325 | — | 1 | — | — | — | 1 | |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
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Drug
General
| Drug common name | FLUDARABINE PHOSPHATE |
| INN | fludarabine |
| Description | Fludarabine phosphate is a purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. It has a role as an antimetabolite, an antineoplastic agent, an immunosuppressive agent, an antiviral agent, a prodrug and a DNA synthesis inhibitor. It is an organofluorine compound, a nucleoside analogue and a purine arabinonucleoside monophosphate. It is functionally related to a 2-fluoroadenine. |
| Classification | Small molecule |
| Drug class | antineoplastics (arabinofuranosyl derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 75607-67-9 |
| RxCUI | 25102 |
| ChEMBL ID | CHEMBL1096882 |
| ChEBI ID | 63599 |
| PubChem CID | 30751 |
| DrugBank | DB01073 |
| UNII ID | P2K93U8740 (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Fludarabine phosphate
Adverse Events
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4,027 adverse events reported
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