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Flucytosine
Ancobon (flucytosine) is a small molecule pharmaceutical. Flucytosine was first approved as Ancobon on 1982-01-01. It is used to treat aids-related opportunistic infections, aspergillosis, candidiasis, chromoblastomycosis, and cryptococcal meningitis amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
nervous system diseasesD009422
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Ancobon (generic drugs available since 2011-06-28)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Flucytosine
Tradename
Company
Number
Date
Products
ANCOBONBausch Health CompaniesN-017001 RX1982-01-01
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
ancobonNew Drug Application2019-08-20
flucytosineNDA authorized generic2023-03-16
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
aids-related opportunistic infectionsD017088
aspergillosisEFO_0007157D001228B44
candidiasisD002177B37
chromoblastomycosisEFO_0007207D002862B43.9
cryptococcal meningitisEFO_0007228D016919B45.1
mycosesD009181B35-B49
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
D01: Antifungals for dermatological use
D01A: Antifungals for topical use
D01AE: Other antifungals for topical use in atc
D01AE21: Flucytosine
J: Antiinfectives for systemic use
J02: Antimycotics for systemic use
J02A: Antimycotics for systemic use
J02AX: Other antimycotics for systemic use in atc
J02AX01: Flucytosine
HCPCS
No data
Clinical
Clinical Trials
51 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD0151793166124
NeoplasmsD009369C8046313
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CholangiocarcinomaD018281C22.1379
Stomach neoplasmsD013274EFO_0003897C1688
Liver neoplasmsD008113EFO_1001513C22.0224
Colonic neoplasmsD003110C18234
Rectal neoplasmsD012004234
Esophageal neoplasmsD004938C1533
AdenocarcinomaD00023033
Bile duct neoplasmsD001650112
Ovarian neoplasmsD010051EFO_0003893C56112
Pancreatic neoplasmsD010190EFO_0003860C2511
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Neoplasm metastasisD009362EFO_000970822
Nasopharyngeal neoplasmsD00930311
Fallopian tube neoplasmsD00518511
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFLUCYTOSINE
INNflucytosine
Description
Flucytosine is an organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections. It has a role as a prodrug. It is an organofluorine compound, a pyrimidone, an aminopyrimidine, a nucleoside analogue and a pyrimidine antifungal drug. It is functionally related to a cytosine.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Nc1nc(=O)[nH]cc1F
Identifiers
PDB
CAS-ID2022-85-7
RxCUI4451
ChEMBL IDCHEMBL1463
ChEBI ID5100
PubChem CID3366
DrugBankDB01099
UNII IDD83282DT06 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 5,948 documents
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Safety
Black-box Warning
Black-box warning for: Ancobon, Flucytosine
Adverse Events
Top Adverse Reactions
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72 adverse events reported
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