Amyvid(florbetapir f 18)
Amyvid (florbetapir f 18) is a small molecule pharmaceutical. Florbetapir f 18 was first approved as Amyvid on 2012-04-06. It has been approved in Europe to treat radionuclide imaging.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| diagnosis | D003933 |
Trade Name
FDA
EMA
Amyvid
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Florbetapir f-18
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AMYVID | Avid Radiopharmaceuticals | N-202008 RX | 2012-04-06 | 2 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| amyvid | New Drug Application | 2020-05-26 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
74 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 16 | 15 | 5 | 5 | 16 | 53 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | 1 | 1 | 3 |
| Postoperative cognitive complications | D000079690 | — | — | — | 1 | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Traumatic brain injuries | D000070642 | S06 | — | 1 | — | — | 2 | 3 | |
| Chronic traumatic encephalopathy | D000070627 | — | 2 | — | — | 1 | 3 | ||
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | 1 | — | — | 1 | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 2 | — | — | — | 2 |
| Vascular dementia | D015140 | F01 | 1 | 1 | — | — | — | 1 | |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | — | 1 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | 1 | 1 | — | — | — | 1 |
| Frontotemporal dementia | D057180 | G31.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 3 | — | — | — | — | 3 | ||
| Progressive supranuclear palsy | D013494 | EFO_0002512 | G23.1 | 2 | — | — | — | — | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | — | — | 2 | 2 | ||
| Primary progressive aphasia | D018888 | EFO_0009053 | G31.01 | — | — | — | — | 1 | 1 |
| Narcolepsy | D009290 | EFO_0000614 | G47.4 | — | — | — | — | 1 | 1 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 1 | 1 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | — | 1 | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FLORBETAPIR F 18 |
| INN | florbetapir (18f) |
| Description | Florbetapir F-18 is an aromatic ether consisting of a pyridine ring substituted at position 2 by a 2-{2-[2-((18)F)fluoroethoxy]ethoxy}ethoxy group and at position 5 and a 2-(4-methylaminophenyl)vinyl group. A positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease. It has a role as a radioactive imaging agent. It is an organofluorine compound, a member of pyridines, an aromatic ether, a (18)F radiopharmaceutical and a substituted aniline. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CNc1ccc(/C=C/c2ccc(OCCOCCOCC[18F])nc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 956103-76-7 |
| RxCUI | 1427224 |
| ChEMBL ID | CHEMBL1774461 |
| ChEBI ID | 66880 |
| PubChem CID | 24822371 |
| DrugBank | DB09149 |
| UNII ID | 6W15Z5R0RU (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 411 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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73,518 adverse events reported
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