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Fasudil
Fasudil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against rho-associated protein kinase 2 and rho-associated protein kinase 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C04: Peripheral vasodilators
— C04A: Peripheral vasodilators
— C04AX: Other peripheral vasodilators in atc
— C04AX32: Fasudil
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
St elevation myocardial infarctionD000072657———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Retinal vein occlusionD012170EFO_1001157H34.81—11——1
Macular edemaD008269——1——1
Retinopathy of prematurityD012178EFO_1001158H35.1—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Amyotrophic lateral sclerosisD000690EFO_0000253G12.21—3———3
DementiaD003704F03—1———1
Progressive supranuclear palsyD013494EFO_0002512G23.1—1———1
Cardiovascular diseasesD002318EFO_0000319I98—1———1
Carotid stenosisD016893—1———1
HypercholesterolemiaD006937HP_0003124—1———1
AtherosclerosisD050197EFO_0003914I25.1—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFASUDIL
INNfasudil
Description
Fasudil is an isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia. It has a role as a geroprotector, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, a vasodilator agent, a nootropic agent, a neuroprotective agent, an antihypertensive agent and a calcium channel blocker. It is a N-sulfonyldiazepane and a member of isoquinolines. It is a conjugate base of a fasudil(1+).
Classification
Small molecule
Drug classvasodilators (undefined group): Rho protein kinase (ROCK) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=S(=O)(c1cccc2cnccc12)N1CCCNCC1
Identifiers
PDB2F2U
CAS-ID103745-39-7
RxCUI—
ChEMBL IDCHEMBL38380
ChEBI ID—
PubChem CID3547
DrugBankDB08162
UNII IDQ0CH43PGXS (ChemIDplus, GSRS)
Target
Agency Approved
ROCK2
ROCK2
ROCK1
ROCK1
Organism
Homo sapiens
Gene name
ROCK2
Gene synonyms
KIAA0619
NCBI Gene ID
9475
Protein name
rho-associated protein kinase 2
Protein synonyms
p164 ROCK-2, Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, ROCK-II
Uniprot ID
O75116
Mouse ortholog
Rock2 (19878)
rho-associated protein kinase 2 (P70336)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,104 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10 adverse events reported
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