Famotidine
Duexis, Pepcid (famotidine) is a small molecule pharmaceutical. Famotidine was first approved as Pepcid on 1986-10-15. It is used to treat duodenal ulcer, dyspepsia, gastroesophageal reflux, heartburn, and helicobacter infections amongst others in the USA. The pharmaceutical is active against histamine H2 receptor.
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COVID-19
Commercial
Trade Name
FDA
EMA
Pepcid ac (generic drugs available since 2001-04-16, discontinued: Fluxid, Pepcid, Pepcid rpd)
CombinationsDuexis, Pepcid complete (generic drugs available since 2001-04-16)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| duexis | New Drug Application | 2021-06-08 |
| maximum strength acid reducer | ANDA | 2023-06-15 |
| pepcid ac | New Drug Application | 2023-04-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| duodenal ulcer | EFO_0004607 | D004381 | K26 |
| dyspepsia | EFO_0008533 | D004415 | K30 |
| gastroesophageal reflux | EFO_0003948 | D005764 | K21 |
| heartburn | — | D006356 | R12 |
| helicobacter infections | EFO_1000961 | D016481 | — |
| peptic esophagitis | EFO_1001095 | D004942 | — |
| stomach ulcer | — | D013276 | K25 |
| urticaria | EFO_0005531 | D014581 | L50 |
| zollinger-ellison syndrome | — | D015043 | E16.4 |
Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| S0028 | Injection, famotidine, 20 mg |
Clinical
Clinical Trials
90 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | 1 | 7 | 3 | 2 | 2 | 14 | |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | 1 | 2 | 2 | 1 | 1 | 5 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | — | 1 | — | 3 |
| Heartburn | D006356 | R12 | 2 | — | — | 1 | — | 3 | |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | 2 | — | 2 | |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | 2 | — | 2 | |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | 1 | 1 | — | 2 |
| Peptic ulcer | D010437 | HP_0004398 | K27 | — | — | — | 2 | — | 2 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | 1 | — | 2 | |
| Anesthesia | D000758 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | — | 1 | 2 |
| Lymphoma | D008223 | C85.9 | — | — | 1 | — | — | 1 | |
| Esophagitis | D004941 | HP_0100633 | K20 | — | — | 1 | — | — | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Laryngomalacia | D055092 | HP_0001601 | 1 | 1 | — | — | 1 | 2 | |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | — | — | — | 1 |
| Brain edema | D001929 | EFO_1000845 | G93.6 | — | 1 | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 1 | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | 1 | — | — | — | 1 | ||
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | — | 1 | — | — | — | 1 |
| Pulmonary arterial hypertension | D000081029 | — | 1 | — | — | — | 1 | ||
| Dyskinesias | D020820 | G24 | — | 1 | — | — | — | 1 | |
| Immunoglobulin g4-related disease | D000077733 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 18 | — | — | — | 2 | 20 | ||
| Drug interactions | D004347 | 2 | — | — | — | — | 2 | ||
| Biological availability | D001682 | 2 | — | — | — | — | 2 | ||
| Neoplasms | D009369 | C80 | 2 | — | — | — | — | 2 | |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Fibrosis | D005355 | 1 | — | — | — | — | 1 | ||
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | — | — | — | — | 1 |
| Colorectal neoplasms | D015179 | 1 | — | — | — | — | 1 | ||
| Non-small-cell lung carcinoma | D002289 | 1 | — | — | — | — | 1 | ||
| Melanoma | D008545 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rhytidoplasty | D015361 | — | — | — | — | 1 | 1 | ||
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | — | 1 | 1 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | 1 | 1 | |
| Respiratory sounds | D012135 | HP_0010307 | R06.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | FAMOTIDINE |
| INN | famotidine |
| Description | Famotidine, sold under the brand name Pepcid among others, is a histamine H2 receptor antagonist medication that decreases stomach acid production. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. It is taken by mouth or by injection into a vein. It begins working within an hour.
|
| Classification | Small molecule |
| Drug class | H2-receptor antagonists (cimetidine type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | NC(N)=Nc1nc(CSCC/C(N)=N/S(N)(=O)=O)cs1 |
Identifiers
| PDB | — |
| CAS-ID | 76824-35-6 |
| RxCUI | 4278 |
| ChEMBL ID | CHEMBL902 |
| ChEBI ID | 4975 |
| PubChem CID | 5702160 |
| DrugBank | DB00927 |
| UNII ID | 5QZO15J2Z8 (ChemIDplus, GSRS) |
Target
Variants
Clinical Variant
No data
Financial
Duexis - Horizon Therapeutics Public
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,334 documents
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Safety
Black-box Warning
Black-box warning for: Duexis
Adverse Events
Top Adverse Reactions
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78,867 adverse events reported
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