Ezogabine
Potiga (ezogabine) is a small molecule pharmaceutical. Ezogabine was first approved as Potiga on 2011-06-10. It is used to treat partial epilepsies in the USA. The pharmaceutical is active against potassium voltage-gated channel subfamily KQT member 4, potassium voltage-gated channel subfamily KQT member 2, potassium voltage-gated channel subfamily KQT member 3, and potassium voltage-gated channel subfamily KQT member 5.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ezogabine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| POTIGA | GSK | N-022345 DISCN | 2011-06-10 | 4 products, RLD |
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| partial epilepsies | EFO_0004263 | D004828 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
221 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Triple negative breast neoplasms | D064726 | — | 6 | 2 | — | — | 8 | ||
| Male breast neoplasms | D018567 | 1 | 1 | 2 | — | 2 | 6 | ||
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | 1 | — | — | 2 |
| Progression-free survival | D000077982 | — | — | 1 | — | — | 1 | ||
| Ductal carcinoma breast | D018270 | — | — | 1 | — | — | 1 | ||
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | 1 | — | — | 1 |
| Sleep wake disorders | D012893 | G47 | — | — | 1 | — | — | 1 | |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | 2 | 1 | — | — | — | 3 | ||
| Bone neoplasms | D001859 | EFO_0003820 | D16 | — | 1 | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | — | — | — | 1 | |
| Phenylketonurias | D010661 | E70.0 | — | 1 | — | — | — | 1 | |
| Prostatic neoplasms | D011471 | C61 | — | 1 | — | — | — | 1 | |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | 1 | |
| Recurrence | D012008 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | C34.90 | 1 | — | — | — | — | 1 | |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arthralgia | D018771 | HP_0002829 | M25.5 | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | — | — | 1 | 1 | |
| Nutrition disorders | D009748 | EFO_0001069 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | EZOGABINE |
| INN | retigabine |
| Description | Ezogabine is a substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults. It has a role as an anticonvulsant and a potassium channel modulator. It is a carbamate ester, an organofluorine compound, a substituted aniline and a secondary amino compound. It is functionally related to a benzene-1,2,4-triamine. |
| Classification | Small molecule |
| Drug class | gabamimetics |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N |
Identifiers
| PDB | — |
| CAS-ID | 150812-12-7 |
| RxCUI | 1112990 |
| ChEMBL ID | CHEMBL41355 |
| ChEBI ID | 68584 |
| PubChem CID | 121892 |
| DrugBank | DB04953 |
| UNII ID | 12G01I6BBU (ChemIDplus, GSRS) |
Target
Agency Approved
KCNQ4
KCNQ4
KCNQ2
KCNQ2
KCNQ3
KCNQ3
KCNQ5
KCNQ5
Organism
Homo sapiens
Gene name
KCNQ4
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily KQT member 4
Protein synonyms
KQT-like 4, potassium channel KQT-like 4, Potassium channel subunit alpha KvLQT4, potassium channel, voltage gated KQT-like subfamily Q, member 4, potassium voltage-gated channel, KQT-like subfamily, member 4, Voltage-gated potassium channel subunit Kv7.4
Uniprot ID
Mouse ortholog
Kcnq4 (60613)
potassium voltage-gated channel subfamily KQT member 4 (Q9JK97)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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11,512 adverse events reported
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