Evofosfamide
Evofosfamide is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 3 | 1 | — | — | 7 |
| Sarcoma | D012509 | 1 | 2 | 1 | — | 1 | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | C61 | 2 | 1 | — | — | — | 2 | |
| Non-small-cell lung carcinoma | D002289 | 1 | 2 | — | — | — | 2 | ||
| Melanoma | D008545 | 1 | 1 | — | — | — | 2 | ||
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | 1 | — | — | — | 2 |
| Multiple myeloma | D009101 | C90.0 | 1 | 1 | — | — | — | 1 | |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | 1 | |
| Biliary tract neoplasms | D001661 | C24.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 5 | — | — | — | — | 5 | |
| Squamous cell carcinoma of head and neck | D000077195 | 1 | — | — | — | — | 1 | ||
| Esophageal neoplasms | D004938 | C15 | 1 | — | — | — | — | 1 | |
| Renal cell carcinoma | D002292 | 1 | — | — | — | — | 1 | ||
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | C92.0 | 1 | — | — | — | — | 1 | |
| Primary myelofibrosis | D055728 | D47.4 | 1 | — | — | — | — | 1 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 1 | — | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | EVOFOSFAMIDE |
| INN | evofosfamide |
| Description | Evofosfamide (INN, USAN; formerly known as TH-302) is an investigational hypoxia-activated prodrug that is in clinical development for cancer treatment. The prodrug is activated only at very low levels of oxygen (hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia.
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| Classification | Small molecule |
| Drug class | phosphoro-derivatives; isophosphoramide mustard derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+](=O)[O-] |
Identifiers
| PDB | — |
| CAS-ID | 918633-87-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL260046 |
| ChEBI ID | — |
| PubChem CID | 11984561 |
| DrugBank | DB06091 |
| UNII ID | 8A9RZ3HN8W (ChemIDplus, GSRS) |
Target
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Safety
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33 adverse events reported
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