Etoricoxib
Etoricoxib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against prostaglandin G/H synthase 2.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
100 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 2 | 6 | 3 | 2 | 13 |
| Postoperative pain | D010149 | G89.18 | — | 1 | 5 | 4 | 1 | 11 | |
| Pain | D010146 | EFO_0003843 | R52 | 1 | 1 | — | 6 | 1 | 9 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | 3 | 2 | 1 | 7 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | 4 | 2 | — | 6 |
| Postherpetic neuralgia | D051474 | — | 1 | — | 1 | — | 2 | ||
| Sprains and strains | D013180 | — | — | — | 2 | — | 2 | ||
| Acute pain | D059787 | R52 | — | — | 1 | 1 | — | 2 | |
| Headache | D006261 | HP_0002315 | R51 | — | — | — | 2 | — | 2 |
| Rupture | D012421 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | — | 2 | — | 2 | 4 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | 1 | — | 1 | 3 |
| Dysmenorrhea | D004412 | HP_0100607 | N94.6 | — | — | 2 | — | — | 2 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | 1 | 1 | — | — | 2 |
| Anterior cruciate ligament injuries | D000070598 | — | — | 1 | — | — | 1 | ||
| Brachial plexus block | D065527 | — | — | 1 | — | — | 1 | ||
| Hysterectomy | D007044 | EFO_0003881 | — | — | 1 | — | — | 1 | |
| Ovariectomy | D010052 | — | — | 1 | — | — | 1 | ||
| Salpingectomy | D058994 | — | — | 1 | — | — | 1 | ||
| Replacement arthroplasty hip | D019644 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acrodynia | D000170 | EFO_1001756 | — | 1 | — | — | — | 1 | |
| Prostatic neoplasms | D011471 | C61 | — | 1 | — | — | — | 1 | |
| Melanoma | D008545 | 1 | 1 | — | — | — | 1 | ||
| Gouty arthritis | D015210 | — | 1 | — | — | — | 1 | ||
| Spine osteoarthritis | D055013 | EFO_1000787 | 1 | 1 | — | — | — | 1 | |
| Hiv | D006678 | O98.7 | — | 1 | — | — | — | 1 | |
| Polyneuropathies | D011115 | EFO_0009562 | A69.22 | — | 1 | — | — | — | 1 |
| Radiculopathy | D011843 | M54.1 | — | 1 | — | — | — | 1 | |
| Causalgia | D002422 | EFO_1000854 | — | 1 | — | — | — | 1 | |
| Peripheral nerve injuries | D059348 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 4 | — | — | — | 1 | 5 | ||
| Therapeutic equivalency | D013810 | 2 | — | — | — | — | 2 | ||
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | — | 1 |
| Myalgia | D063806 | HP_0003326 | M79.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Edema | D004487 | R60.9 | — | — | — | — | 1 | 1 | |
| Trismus | D014313 | — | — | — | — | 1 | 1 | ||
| Male breast neoplasms | D018567 | — | — | — | — | 1 | 1 | ||
| Anesthesia | D000758 | — | — | — | — | 1 | 1 | ||
| Conduction anesthesia | D000765 | — | — | — | — | 1 | 1 | ||
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 1 | 1 |
| Gout | D006073 | EFO_0004274 | M10 | — | — | — | — | 1 | 1 |
| Spondylarthropathies | D025242 | EFO_0000706 | M47 | — | — | — | — | 1 | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ETORICOXIB |
| INN | etoricoxib |
| Description | Etoricoxib is a member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is a sulfone, a member of bipyridines and an organochlorine compound. |
| Classification | Small molecule |
| Drug class | cyclooxygenase-2 inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(-c2ncc(Cl)cc2-c2ccc(S(C)(=O)=O)cc2)cn1 |
Identifiers
| PDB | 3CFL |
| CAS-ID | 202409-33-4 |
| RxCUI | 307296 |
| ChEMBL ID | CHEMBL416146 |
| ChEBI ID | 6339 |
| PubChem CID | 123619 |
| DrugBank | DB01628 |
| UNII ID | WRX4NFY03R (ChemIDplus, GSRS) |
Target
Agency Approved
PTGS2
PTGS2
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,431 adverse events reported
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