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Etidronic acid
Didronel (etidronic acid) is a small molecule pharmaceutical. Etidronic acid was first approved as Didronel on 1982-01-01. It is used to treat extramammary paget disease, heterotopic ossification, and hypercalcemia in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Etidronate disodium
Tradename
Company
Number
Date
Products
DIDRONELAllerganN-017831 DISCN1982-01-01
2 products, RLD
DIDRONELMGI PharmaN-019545 DISCN1987-04-20
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
extramammary paget disease—D010145—
heterotopic ossification—D009999—
hypercalcemiaHP_0003072D006934E83.52
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M05: Drugs for treatment of bone diseases
— M05B: Drugs affecting bone structure and mineralization
— M05BA: Bisphosphonate drugs affecting bone structure and mineralization
— M05BA01: Etidronic acid
— M05BB: Bisphosphonates, combinations affecting bone structure and mineralization
— M05BB01: Etidronic acid and calcium, sequential
V: Various drug classes in atc
— V10: Therapeutic radiopharmaceuticals
— V10B: Pain palliation (bone seeking agents)
— V10BX: Various pain palliation radiopharmaceuticals
— V10BX03: Rhenium (186re) etidronic acid
HCPCS
No data
Clinical
Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameETIDRONIC ACID
INNetidronic acid
Description
Etidronic acid is a 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces. It has a role as a bone density conservation agent, a chelator and an antineoplastic agent. It is a conjugate acid of an etidronic acid(2-).
Classification
Small molecule
Drug classcalcium metabolism regulators
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(O)(P(=O)(O)O)P(=O)(O)O
Identifiers
PDB—
CAS-ID2809-21-4
RxCUI1356715
ChEMBL IDCHEMBL871
ChEBI ID4907
PubChem CID3305
DrugBankDB01077
UNII IDM2F465ROXU (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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